Modulation of TIM receptor activity in combination with cytoreductive therapy
A genetic locus and corresponding family of proteins associated with regulation of immune function and cell survival are provided. These genes encode cell surface molecules with conserved IgV and mucin domains. The locus comprising the TIM family is genetically associated with immune dysfunction, including asthma. Furthermore, the TIM gene family is located within a region of human chromosome 5 that is commonly deleted in malignancies and myelodysplastic syndrome. Polymorphisms in the gene sequences are associated with the development of airway hyperreactivity and allergic inflammation, and T cell production of IL-4 and IL-13. The proteins include the human hepatitis A cellular receptor, hHAVcr-1.
1. A method for the treatment of cancer in an individual, the method comprising:
administering to said individual an agonistic antibody that specifically binds to TIM1.
2. The method of claim 1 , wherein the cancer is breast cancer.
3. The method of claim 2 , wherein the cancer is metastatic breast cancer.
4. The method of claim 1 , further administering in combination with the agonistic antibody that binds to TIM1, an effective dose of a cytoreductive agent.
5. The method according to claim 1 , wherein said antibody is an agonist of TIM-1 and potentiates the effect of chemotherapeutic agents or radiation therapy.