PACKAGING AND DISPENSING OF RAPID DISSOLVE DOSAGE FORM
An oral dosage delivery vehicle comprising an edible film including a uniformly distributed active ingredient, wherein said film comprises dosage units releasably joined by one or more weakened sections, which permit said dosage units to be detached from said film.
1 . An oral dosage delivery vehicle comprising an edible film including a uniformly distributed active ingredient, wherein said film comprises dosage units releasably joined by one or more weakened sections, which permit said dosage units to be detached from said film.
2 . The delivery vehicle of claim 1 , wherein said film is self-supporting.
3 . The delivery vehicle of claim 1 , wherein said weakened sections are perforations.
4 . The delivery vehicle of claim 1 , wherein said weakened sections are scored.
5 . The delivery vehicle of claim 1 , wherein said active is a pharmaceutical or cosmetic active.
6 . The delivery vehicle of claim 1 , wherein said active varies no more than 10% among said dosage units.
7 . The delivery vehicle of claim 1 , wherein said film includes a carrier layer of a substantially water insoluble material.
8 . The delivery vehicle of claim 3 , wherein said carrier layer is substantially continuous.
9 . The delivery vehicle of claim 3 , wherein said carrier layer includes weakened sections that correspond to the weakened sections of said film.
10 . The delivery vehicle of claim 1 , wherein the film has a surface with a surface area comprising voids that increase the surface area.
11 . The delivery vehicle of claim 10 , wherein said voids increase the speed of dissolution of said delivery vehicle.
12 . The delivery vehicle of claim 10 , wherein the voids are selected from the group consisting of voids that go through the entire depth of the film, voids that go through a portion of the depth of the film, and voids that are formed by casting the film on a patterned template.
13 . The delivery vehicle of claim 10 , wherein said voids are uniform and maintain the uniform distribution of the active.
14 . An oral dosage delivery vehicle comprising an edible film, wherein said film comprises dosage units releasably joined by one or more weakened sections, which permit said dosage units to be detached from said film.
15 . The delivery vehicle of claim 14 , wherein said weakened sections contain less film composition than surrounding areas.
16 . The delivery vehicle of claim 14 , wherein said film is self-supporting.
17 . The delivery vehicle of claim 14 , wherein said weakened sections are perforations.
18 . The delivery vehicle of claim 14 , wherein said weakened sections are scored.
19 . The delivery vehicle of claim 14 , wherein said weakened sections are thinner than surrounding area.
20 . The delivery vehicle of claim 14 , further comprising an active ingredient.
21 . The delivery vehicle of claim 20 , wherein said active is a pharmaceutical or cosmetic active.
22 . The delivery vehicle of claim 20 , wherein said active is uniformly distributed.
23 . The delivery vehicle of claim 20 , wherein said active varies no more than 10% among said dosage units.
24 . The delivery vehicle of claim 14 , wherein said film includes a carrier layer of a substantially water insoluble material.
25 . The delivery vehicle of claim 17 , wherein said carrier layer is substantially continuous.
26 . The delivery vehicle of claim 17 , wherein said carrier layer includes weakened sections that correspond to the weakened sections of said film.
27 . The delivery vehicle of claim 22 , wherein the film has a surface with a surface area comprising voids that increase the surface area.
28 . The delivery vehicle of claim 27 , wherein the voids are selected from the group consisting of voids that go through the entire depth of the film, voids that go through a portion of the depth of the film, and voids that are formed by casting the film on a patterned template.
29 . The delivery vehicle of claim 27 , wherein said voids are uniform and maintain the uniform distribution of the active.
30 . A package for the storage and dispensing of a sheet-like rapid dissolve dosage form, comprising:
a) a pouch comprising a top layer and a bottom layer each having an outer edge, wherein said top and bottom layers are sealed at the respective outer edges to define an enclosed interior surface therewithin, and
b) a sheet-like rapid dissolve dosage form contained within said enclosed space.
31 . The package of claim 30 , wherein said dosage form includes an active ingredient and comprises a sheet of one or more dosage forms.
32 . The package of claim 31 , wherein said dosage form includes weakened sections.
33 . The package of claim 31 , wherein said weakened sections include perforations.
34 . The package of claim 31 , wherein said weakened sections are thinner than surrounding area.
35 . The package of claim 32 , wherein said weakened sections form one or more equally spaced lines in a direction selected from vertical, horizontal, and combinations thereof.
36 . The package of claim 30 , wherein said pouch is resealable.
37 . A method of storing a sheet-like rapid dissolve dosage form comprising the steps of:
a) preparing a sheet-like dosage form that includes an active ingredient;
b) defining said dosage form into a plurality of substantially equal weakened sections separable dosage units by forming in said dosage form;
c) preparing a pouch comprising top and bottom layers each having an outer edge;
d) placing said dosage form between said top and bottom layers; and
e) sealing the outer edges of said pouch.
38 . A method of dispensing a sheet-like dosage form comprising the steps of:
a) preparing a sheet-like dosage form that includes an active ingredient;
b) separating said dosage form by weakened sections into segments of substantially equal area;
c) preparing a pouch comprising top and bottom layers each of said layers having an edge surrounding the circumference of said layer;
d) placing said dosage form between said top and bottom layers;
e) separably sealing a portion of said edges of said pouch;
f) opening a portion of said pouch;
g) opening one or more of said sections of said dosage form along said perforations; and
h) removing said one or more segments from said pouch.
39 . The method of claim 38 , further comprising the step of resealing said pouch.
40 . The method of claim 38 , further comprising the step of permanently sealing the remaining portion of the edges of said pouch.