Solid support with a grafted chain
View Patent ↗Articles that contain a solid support with a grafted chain extending from the solid support, methods of making these articles, and various uses of the articles are described. More specifically, the grafted chain has a functional group that can react with or interact with target compound. Alternatively, the functional group on the grafted chain can react with a modifying agent to provide another group that can react with or interact with the target compound. The grafted chains are attached to the solid support through a ring-opened azlactone group. The articles can be used to purify the target compound or to separate the target compound from other molecules in a sample.
1. An article comprising a (meth)acryloyl-functionalized support of Formula (II)
SS-(CO)—NH—C(R 1 ) 2 —(CH 2 ) p —(CO)-Q-Y 1 -Q-(CO)—CR 2 ═CH 2 (II)
wherein
SS is a solid support;
p is an integer equal to 0 or 1;
each R 1 is independently selected from alkyl, heteroalkyl, aryl, or aralkyl;
each Q is independently a divalent group selected from oxy, thio, or —NR 3 — where R 3 is hydrogen, alkyl, heteroalkyl, aryl, or aralkyl;
Y 1 is a first linking group that comprises an alkylene, heteroalkylene, arylene, or combination thereof; and
each R 2 is independently hydrogen or an alkyl.
2. The article of claim 1 , wherein the solid support is in the form of a bead.
3. The article of claim 1 , wherein the solid support comprises a crosslinked polymeric material.
4. The article of claim 1 , wherein the solid support is in the form of a membrane, foam, film, sheet, or coating on a substrate.
5. The article of claim 1 , wherein each Q is oxy.
6. The article of claim 1 , wherein Y 1 is an alkylene.
7. An article comprising a grafted support of Formula (IV)
SS-(CO)—NH—C(R 1 ) 2 —(CH 2 ) p —(CO)-Q-Y 1 -Q-(CO)—CR 2 U 2 —CH 2 —U 1 (IV)
wherein
SS comprises a solid support in the form of a membrane, foam, film, sheet, or coating on a substrate;
p is an integer equal to 0 or 1;
each R 1 is each independently selected from alkyl, heteroalkyl, aryl, or aralkyl;
each Q is independently a divalent group selected from oxy, thio, or —NR 3 — where R 3 is hydrogen, alkyl, heteroalkyl, aryl, or aralkyl;
Y 1 is a first linking group that comprises an alkylene, heteroalkylene, arylene, or combination thereof;
each R 2 is independently hydrogen or an alkyl;
U 1 comprises at least one divalent monomeric unit of formula —CR 2 (Y 2 Z 1 )—CH 2 —;
U 2 is hydrogen or comprises at least one divalent monomeric unit of formula —CR 2 (Y 2 Z 1 )—CH 2 —;
Y 2 is a second linking group selected from a single bond or a divalent group comprising an alkylene, heteroalkylene, arylene, or combination thereof; and
Z 1 is a functional group selected from (1) an acidic group or a salt thereof, (2) an amino group or a salt thereof, (3) a hydroxyl group, (4) an azlactone group or a precursor of the azlactone group, (5) a glycidyl group, or (6) a combination thereof.
8. The article of claim 7 , wherein each Q is oxy.
9. The article of claim 7 , wherein Y 1 is an alkylene.