Modified pectins, compositions and methods related thereto
View Patent ↗The present invention provides compositions of modified pectin and methods for preparing and using them.
1. A method of treating chronic inflammation in a patient in need thereof, comprising parenterally administering to the patient a therapeutically effective amount of an aqueous solution of a purified modified pectin or a purified, deesterified, and partially depolymerized modified pectin, wherein the solution is substantially free of modified pectins having molecular weights below 25 kD.
2. The method of claim 1 , wherein the average molecular weight of the purified modified pectin or purified, deesterified, and partially depolymerized modified pectin is from 50-200 kD.
3. The method of claim 2 , wherein the average molecular weight of the modified pectin or deesterified and partially depolymerized modified pectin is from 70-150 kD.
4. A method of treating chronic inflammation in a patient in need thereof, comprising parenterally administering to the patient a therapeutically effective amount of an aqueous solution of a purified modified pectin or a purified, deesterified, and partially depolymerized modified pectin, wherein the average molecular weight of the purified modified pectin or purified, deesterified, and partially depolymerized modified pectin is from 70-150 kD.
5. The method of claim 4 , wherein the average molecular weight of the purified modified pectin or purified, deesterified, and partially depolymerized modified pectin is from 80-150 kD.
6. The method of claim 5 , wherein the average molecular weight of the modified pectin or deesterified and partially depolymerized modified pectin is from 80-100 kD.
7. The method of claim 4 , wherein the aqueous solution is substantially free of modified pectins having molecular weights below 25 kD.
8. The method of claim 1 , wherein the solution contains at least 0.5% by weight of the modified pectin or deesterified and partially depolymerized modified pectin.
9. The method of claim 8 , wherein the solution contains at least 5% by weight of the modified pectin or deesterified and partially depolymerized modified pectin.
10. The method of claim 4 , wherein the solution contains at least 0.5% by weight of the modified pectin or deesterified and partially depolymerized modified pectin.
11. The method of claim 10 , wherein the solution contains at least 5% by weight of the modified pectin or deesterified and partially depolymerized modified pectin.
12. The method of claim 1 , wherein the aqueous solution comprises a deesterified and partially depolymerized modified pectin.
13. The method of claim 4 , wherein the aqueous solution comprises a deesterified and partially depolymerized modified pectin.
14. The method of claim 1 , wherein the aqueous solution comprises a modified pectin.
15. The method of claim 4 , wherein the aqueous solution comprises a modified pectin.
16. The method of claim 14 , wherein the modified pectin consists essentially of a homogalacturonan backbone with small amounts of rhamnogalacturonan therein, wherein the backbone has neutral sugar side chains having a low degree of branching dependent from the backbone.
17. The method of claim 16 , wherein the galacturonic acid subunits of the backbone have been substantially deesterified.
18. The method of claim 15 , wherein the modified pectin consists essentially of a homogalacturonan backbone with small amounts of rhamnogalacturonan therein, wherein the backbone has neutral sugar side chains having a low degree of branching dependent from the backbone.
19. The method of claim 18 , wherein the galacturonic acid subunits of the backbone have been substantially deesterified.
20. The method of claim 1 , wherein parenterally administering comprises injection or intravenous infusion.
21. The method of claim 4 , wherein parenterally administering comprises injection or intravenous infusion.