IP Library › Granted Patent US 9,505,831
Granted Patent B2
US 9,505,831 · App. 14/256,300 · Granted Nov 29, 2016

Isolated cell comprising a nucleic acid encoding antibody inhibitors of gdf-8 and uses thereof

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Quick Facts
Patent No.
US 9,505,831
App. No.
14/256,300
Granted
Nov 29, 2016
Kind
B2
Abstract

The disclosure provides novel antibodies against growth and differentiation factor-8 (GDF-8), including antibody fragments, which inhibit GDF-8 activity in vitro and in vivo. The disclosure also provides methods for diagnosing, preventing, or treating degenerative disorders of muscle, bone, or insulin metabolism.

Claims (7)

1. An isolated cell comprising a nucleic acid encoding an antibody that specifically binds to amino acids 1-50 of the polypeptide of SEQ ID NO: 15, wherein the antibody reduces Growth and Differentiation Factor-8 (GDF-8) activity.

2. The cell of claim 1 , wherein the antibody specifically binds to amino acids 1-25 of the polypeptide of SEQ ID NO: 15.

3. The cell of claim 2 , wherein the antibody specifically binds to amino acids 1-15 of the polypeptide of SEQ ID NO: 15.

4. An isolated cell comprising a nucleic acid molecule encoding an antibody that specifically binds to the polypeptide of SEQ ID NO:2, wherein the antibody reduces GDF-8 activity.

5. An isolated cell comprising a nucleic acid molecule encoding an antibody that specifically binds to the polypeptide of SEQ ID NO:3, wherein the antibody reduces GDF-8 activity.

6. An isolated cell comprising a nucleic acid molecule encoding an antibody that specifically binds to the polypeptide of SEQ ID NO:5, wherein the antibody reduces GDF-8 activity.

7. An isolated cell comprising a nucleic acid molecule encoding an antibody that specifically binds to the polypeptide of SEQ ID NO:8, wherein the antibody reduces GDF-8 activity.