IP Library Granted Patent US 8,882,797
Granted Patent B2
US 8,882,797 · App. 14/258,504 · Granted Nov 11, 2014

Methods of embolic filtering

Inventors: Vallabh Janardhan (Dallas, TX); Vikram Janardhan (Sacramento, CA)
Assignee: Insera Therapeutics, Inc.
A61F2/013A61B2017/22034A61F2002/011A61B2017/22002A61B17/22032A61M29/00A61B2017/22001A61B2017/00778
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Quick Facts
Patent No.
US 8,882,797
App. No.
14/258,504
Granted
Nov 11, 2014
Kind
B2
Abstract

Methods of providing embolic protection during treatment of a vessel include advancing a microcatheter in the vessel, inserting a textile structure in a collapsed state into the microcatheter, and advancing the textile structure through the microcatheter. The methods may include, after advancing the textile structure and retracting the microcatheter to unsheathe a self-expanding bulb of the textile structure from the microcatheter, thereby allowing the self-expanding bulb to self-expand from the collapsed state to an expanded state. The methods may include performing a vascular procedure. In the expanded state, the self-expanding bulb may filter emboli released during performing the vascular procedure.

Claims (45)

1. A method of providing embolic protection during treatment of a vessel, the method comprising:

advancing a microcatheter in the vessel, wherein advancing the microcatheter includes crossing a thrombus with a distal end of the microcatheter;

inserting a textile structure in a collapsed state into the microcatheter, the textile structure comprising a plurality of self-expanding bulbs and a plurality of necks,

wherein the plurality of self-expanding bulbs comprises five to twenty self-expanding bulbs, each of the plurality of self expanding bulbs having a spherical shape or an oblong shape,

wherein pairs of the self-expanding bulbs are spaced by a neck of the plurality of necks;

advancing the textile structure through the microcatheter proximate to the distal end of the microcatheter, wherein advancing the textile structure includes crossing the thrombus with a distal-most bulb of the plurality of self-expanding bulbs;

after advancing the textile structure, retracting the microcatheter to unsheathe a length of the textile structure, wherein retracting the microcatheter to unsheathe the length of the textile structure comprises:

unsheathing at least the distal-most bulb of the plurality of self-expanding bulbs from the microcatheter, and

self-expanding at least the distal-most bulb of the plurality of self-expanding bulbs from the collapsed state to an expanded state; and

removing the thrombus from the vessel,

wherein, in the expanded state, the distal-most bulb:

apposes sidewalls of the vessel, and

filters emboli released during the removing the thrombus from the vessel.

2. The method of claim 1 , wherein removing the thrombus comprises further retracting the microcatheter to unsheathe another length of the textile structure comprising other bulbs of the plurality of self-expanding bulbs, wherein, upon being unsheathed from the microcatheter, the other bulbs self-expand from the collapsed state to an expanded state, the other bulbs entrapping the thrombus.

3. The method of claim 2 , further comprising torsionally rasping the textile structure, the distal-most bulb of the plurality of self-expanding bulbs providing a distal anchor for the torsionally rasping.

4. The method of claim 1 , wherein removing the thrombus comprises deploying a thrombectomy device proximal to the distal-most bulb of the plurality of self-expanding bulbs, the thrombectomy device different than the textile structure.

5. The method of claim 4 , wherein deploying the thrombectomy device includes crossing the thrombus with a distal section of the thrombectomy device.

6. The method of claim 4 , further comprising, at least one of after and during removing the thrombus from the vessel, further retracting the microcatheter, wherein further retracting the microcatheter comprises unsheathing other bulbs of the plurality of self-expanding bulbs and self-expanding the other bulbs of the plurality of self-expanding bulbs from the collapsed state to an expanded state, the other bulbs of the plurality of self-expanding bulbs in the expanded state entrapping residual thrombus.

7. The method of claim 1 , wherein retracting the microcatheter to unsheathe the length of the textile structure comprises expanding the vessel.

8. A method of providing embolic protection during treatment of a vessel, the method comprising:

advancing a microcatheter in the vessel;

inserting a textile structure in a collapsed state into the microcatheter, the textile structure comprising a plurality of self-expanding bulbs and a plurality of necks, pairs of the self-expanding bulbs spaced by a neck of the plurality of necks;

advancing the textile structure through the microcatheter proximate to a distal end of the microcatheter;

after advancing the textile structure, retracting the microcatheter to unsheathe a length of the textile structure, wherein retracting the microcatheter to unsheathe the length of the textile structure comprises:

unsheathing at least a distal-most bulb of the plurality of self-expanding bulbs from the microcatheter, and

self-expanding at least the distal-most bulb of the plurality of self-expanding bulbs from the collapsed state to an expanded state; and

performing a vascular procedure, wherein performing the vascular procedure comprises using a vascular device different than the textile structure,

wherein, in the expanded state, the distal-most bulb of the plurality of self-expanding bulbs filters emboli released during performing the vascular procedure,

torsionally rasping the textile structure, the distal-most bulb of the plurality of self-expanding bulbs providing a distal anchor for the torsionally rasping.

9. The method of claim 8 , further comprising, at least one of after and during performing the vascular procedure, further retracting the microcatheter, wherein further retracting the microcatheter comprises unsheathing other bulbs of the plurality of self-expanding bulbs and self-expanding the other bulbs of the plurality of self-expanding bulbs from the collapsed state to an expanded state, the other bulbs of the plurality of self-expanding bulbs in the expanded state entrapping residual emboli.

10. The method of claim 8 , wherein the distal-most bulb of the plurality of self-expanding bulbs in the expanded state comprises a spherical shape or an oblong shape.

11. The method of claim 8 , wherein the vascular procedure comprises thrombectomy.

12. The method of claim 8 , wherein the vascular procedure comprises at least one of angioplasty, atherectomy, aspiration, stenting, embolic coil insertion, intra-arterial thrombolysis, and bypass.

13. The method of claim 8 , wherein retracting the microcatheter to unsheathe the length of the textile structure comprises expanding the vessel.

14. A method of providing embolic protection during treatment of a vessel, the method comprising:

advancing a microcatheter in the vessel;

inserting a woven textile structure in a collapsed state into the microcatheter;

advancing the textile structure through the microcatheter proximate to a distal end of the microcatheter;

after advancing the textile structure, retracting the microcatheter to unsheathe a self-expanding bulb from the microcatheter, thereby allowing the self-expanding bulb to self-expand from the collapsed state to an expanded state; and

performing a vascular procedure, wherein, in the expanded state, the self-expanding bulb filters emboli released during performing the vascular procedure,

at least one of after and during performing the vascular procedure, further retracting the microcatheter, wherein further retracting the microcatheter comprises unsheathing other self-expanding bulbs and self-expanding the other self-expanding bulbs from the collapsed state to an expanded state, the other self-expanding bulbs in the expanded state entrapping residual emboli.

15. The method of claim 14 , further comprising torsionally rasping the textile structure, the self-expanding bulb providing an anchor for the torsionally rasping.

16. The method of claim 13 , wherein the vascular procedure comprises thrombectomy.

17. The method of claim 14 , wherein the vascular procedure comprises at least one of angioplasty, atherectomy, aspiration, stenting, embolic coil insertion, intra-arterial thrombolysis, and bypass.

18. The method of claim 14 , wherein retracting the microcatheter to unsheathe the self-expanding bulb comprises expanding the vessel.

Assignments (3)
RELEASE OF SECURITY INTEREST Recorded Sep 9, 2021
From: KNOBBE, MARTENS, OLSON & BEAR, LLP
To: INSERA THERAPEUTICS, INC.
Reel/Frame 057454/0677 →
SECURITY INTEREST Recorded Jun 30, 2020
From: INSERA THERAPEUTICS, INC.
To: KNOBBE, MARTENS, OLSON & BEAR, LLP
Reel/Frame 053095/0350 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Apr 22, 2014
From: JANARDHAN, VALLABH; JANARDHAN, VIKRAM
To: INSERA THERAPEUTICS, INC.
Reel/Frame 032731/0762 →
Continuity (4)
Continuation 13953540 · Jul 29, 2013
Continuation In Part 13952982 · Jul 29, 2013
Provisional Application 61798540 · Mar 15, 2013
Related Publication 20140277098A1 · Sep 18, 2014