Methods and compositions for wound healing
The present invention relates to methods and compositions for wound healing. In particular, the present invention relates to promoting and enhancing wound healing by utilizing cross-linker covalent modification molecules to attach and deliver wound active agents to a wound. In addition, the present invention provides methods and compositions utilizing oppositely charged polymers to form a polyelectrolyte layer on a wound surface. The invention further relates to incorporating wound active agents into a polyelectrolyte layer for delivery to a wound.
1. A membrane comprising a polyelectrolyte multilayer comprising cationic and anionic polymers directly supported on a solid support selected from the group consisting of a polyvinyl alcohol membrane and a polyethylene oxide membrane, said polyelectrolyte multilayer comprising a silver antimicrobial compound and analgesic agent incorporated therein and having a thickness of from 1 to 1,000 nm and a compliance of from 3 to 500 kPa.
2. The article of claim 1 , wherein said polyelectrolyte multilayer is functionalized.
3. The article of claim 1 , wherein said antimicrobial agent is distributed within said polyelectrolyte multilayer so that a gradient is formed.
4. A method comprising,
applying the article of claim 1 to a wound on a subject, wherein said article enhances healing of said wound.
5. A kit comprising the article of claim 1 in a sterile package.