System and method for bronchial dilation
View Patent ↗A method of reducing bronchial constriction in a subject includes delivering energy to create one or more lesions on a main bronchus so as to transect pulmonary nerves sufficiently to reduce bronchial constriction in a lung of the patient distal to the main bronchus.
1. A system, comprising:
an implantable signal generator configured to generate a blocking signal to be delivered to nerve tissue proximate a bronchus or trachea of a patient;
an electrode operatively coupled to the signal generator and configured to be coupled proximate the bronchus or trachea to deliver energy from the implantable signal generator to the nerve tissue, wherein the electrode is configured to at least partially surround at least a portion of the bronchus; and
a processor, communicatively coupled to the implantable signal generator, the processor configured to receive information regarding a patient physiological parameter and, using the received information about the patient physiological parameter, to cause the implantable signal generator to activate, deactivate, increase, or decrease delivery of the blocking signal through the electrode to the nerve tissue so as to have an effect on the patient, the effect being selected from the group consisting of: impeding nerve signal traffic to a lung of the patient, impeding nerve signal traffic from a lung of the patient, relieving bronchial smooth muscle contraction, inhibiting cough, allowing nerve signal traffic to and/or from the lung of the patient to provide general pulmonary maintenance, and combinations thereof.
2. The system of claim 1 , wherein the electrode is configured to be implanted in contact with a post-ganglionic ascending afferent pulmonary nerve of a pulmonary nerve trunk.
3. The system of claim 1 , wherein the electrode is configured to be implanted in contact with a post-ganglionic descending efferent pulmonary nerve of a pulmonary nerve trunk.
4. The system of claim 1 , wherein the electrode is configured to be implanted in contact with a pre-ganglionic vagus nerve of a pulmonary trunk.
5. The system of claim 1 , wherein the electrode is configured to be implanted in contact with at least one of a pulmonary plexus or a pulmonary ganglia.
6. The system of claim 1 , wherein the electrode comprises a cuff electrode configured to at least partially surround at least a portion of the bronchus.
7. The system of claim 1 , wherein the processor is configured to deliver the blocking signal at a frequency between 10 and 5000 Hertz, at an amplitude between 0.1 and 10 milliamps, and with a pulse width between 50 microseconds and 2 milliseconds.
8. The system of claim 1 , wherein the processor is configured to receive information regarding a patient physiological parameter comprising physical activity.
9. The system of claim 8 , wherein the physical activity is sensed via an accelerometer coupled to the implantable signal generator.
10. The system of claim 1 , wherein the processor is configured to receive information regarding a patient physiological parameter comprising bronchial diameter.
11. The system of claim 10 , wherein the bronchial diameter is measured via a sensor selected from the group consisting of a strain gauge, an impedance sensor, or combinations thereof.
12. The system of claim 1 , wherein the processor is configured to vary one or more characteristics of the blocking signal over time so as to prevent or inhibit the nervous system from adapting to the blocking signal and to maintain efficacy of the blocking signal.
13. The system of claim 1 , wherein the system is configured to activate, alter, or cease therapy during periods of exacerbation, wherein exacerbation is sensed using one or more physiological parameters selected from the group consisting of breathlessness, cough, sputum or mucus production, mucus color, mucus thickness, wheezing, thoracic pressure, chest tightness, pain, or combinations thereof.
14. The system of claim 1 , wherein the system includes one or more cough sensors configured to receive an indication of acute or chronic cough, wherein the one or more cough sensors is selected from the group consisting of pressure sensors, respiration sensors, sound sensors, activity sensors, impedance sensors, phrenic nerve inputs, and combinations thereof, and wherein, upon sensing or detecting cough, the system is configured to inhibit or reduce an ability of a subject to cough by providing a blocking signal, or to allow cough by ceasing delivery of blocking signals.
15. The system of claim 14 , wherein the one or more cough sensors comprises a respiration sensor selected from the group consisting of a tidal volume sensor, minute ventilation sensor, or combinations thereof, configured to detect a change in respiration indicative of a cough.
16. The system of claim 14 , wherein the one or more cough sensors comprises a sound sensor selected from the group consisting of an accelerometer, a microphone, or combinations thereof, configured to detect a change in sound indicative of a cough.
17. The system of claim 14 , wherein the one or more cough sensors comprises an activity sensor configured to detect a vibration, motion, or other activity of the patient indicative of a cough.
18. The system of claim 14 , wherein the one or more cough sensors comprises an impedance sensor configured to detect impedance indicative of fluid buildup, accumulation, or a change in consistency of the lungs, bronchi, or airway indicative of a likely period of cough or mucus buildup.
19. The system of claim 1 , wherein the system is configured to detect and apply the blocking signal during periods of hyperinflation, the hyperinflation being detected by an increase in patient activity, an increase in breathing frequency, a decrease in respiration volume, or combinations thereof.
20. The system of claim 1 , wherein the system is configured to provide the blocking signal in conjunction with drug stimulation.
21. The system of claim 1 , wherein the system is configured to detect a narrow bronchial passage using a detected pressure through the airway, a detected volume of air through the airway, or using a relationship between both, and wherein upon detection of the narrow bronchial passage, the system is configured to provide the blocking signal to relieve smooth muscle contraction.
22. A method, comprising:
providing a system to a user, the system including:
an implantable signal generator;
an electrode operatively coupled to the signal generator and configured to be coupled proximate a bronchus or trachea of a patient, wherein the electrode is configured to at least partially surround at least a portion of the bronchus; and
a processor, communicatively coupled to the implantable signal generator; and
providing instructions to the user, the instructions including:
causing the implantable signal generator to activate, deactivate, increase, or decrease delivery of a blocking signal to be delivered via the electrode to nerve tissue proximate the bronchus or trachea, the blocking signal based at least in part on information received by the processor indicative of a patient physiological parameter, the blocking signal configured to have an effect selected from the group consisting of inhibiting nerve signal traffic to or from a lung of the patient, relieving bronchial smooth muscle contraction, inhibiting cough, allowing nerve signal traffic to and/or from the lung of the patient to provide general pulmonary maintenance, and combinations thereof.
23. The method of claim 22 , wherein providing a system to a user comprises causing the system to be manufactured and made available to the user.
24. The method of claim 22 , wherein the instructions further comprise implanting the electrode in contact with a post-ganglionic ascending afferent pulmonary nerve of a pulmonary nerve trunk.
25. The method of claim 22 , wherein the instructions further comprise implanting the electrode in contact with a post-ganglionic descending efferent pulmonary nerve of a pulmonary nerve trunk.
26. The method of claim 22 , wherein the instructions further comprise implanting the electrode in contact with a pre-ganglionic vagus nerve of a pulmonary trunk.
27. The method of claim 22 , wherein the instructions further comprise implanting the electrode in contact with at least one of a pulmonary plexus or a pulmonary ganglia.
28. The method of claim 22 , wherein the electrode comprises a cuff electrode, and wherein the instructions further comprise implanting the cuff electrode so as to at least partially surround at least a portion of the bronchus.
29. The method of claim 22 , wherein the instructions further comprise causing the processor to deliver the blocking signal at a frequency between 10 and 5000 Hertz, at an amplitude between 0.1 and 10 milliamps, and with a pulse width between 50 microseconds and 2 milliseconds.
30. The method of claim 22 , wherein the instructions further comprise causing the processor to vary one or more characteristics of the blocking signal over time so as to prevent the nervous system from adapting to the blocking signal and to maintain efficacy of the blocking signal.