Oligomer-calcium channel blocker conjugates

1. A compound having the structure:

wherein:

R is hydrogen or lower alkyl;

R 1 is selected from the group consisting of hydrogen, substituted lower alkyl, unsubstituted lower alkyl and —YOYNR 6 R 7 , where each Y is independently lower alkylene and R 6 and R 7 are each independently selected from group consisting of hydrogen, unsubstituted lower alkyl, substituted lower alkyl, cycloalkyl, aryl and alkylaryl;

each Y is independently lower alkylene;

R 3 and R 4 are independently selected from the group consisting of hydrogen, unsubstituted lower alkyl, substituted lower alkyl, and —YNR 6 R 7 , where Y is lower alkylene and R 6 and R 7 are each independently selected from group consisting of hydrogen, unsubstituted lower alkyl, substituted lower alkyl, cycloalkyl, aryl and alkylaryl;

R 5 is independently selected from group consisting of hydrogen, unsubstituted lower alkyl, substituted lower alkyl, chloro, fluoro and nitro;

R 6 is selected from group consisting of hydrogen, unsubstituted lower alkyl, substituted lower alkyl, cycloalkyl, aryl and alkylaryl;

X is a spacer moiety; and

POLY is a water-soluble oligomer wherein the number of monomers has a number between 2 and 30.

2. The compound of claim 1 , wherein the water-soluble, non-peptidic oligomer is a poly(alkylene oxide).

3. The compound of claim 2 , wherein the poly(alkylene oxide) is a poly(ethylene oxide).

4. The compound of claim 2 , wherein the poly(alkylene oxide) includes an alkoxy or hydroxy end-capping moiety.

5. The compound of claim 1 , having the structure:

wherein n is an integer of from 2 to 10.

6. The compound of claim 1 , having the structure:

wherein n is an integer of from 2 to 10.