Compounds that modulate intracellular calcium
View Patent ↗Described herein are compounds and pharmaceutical compositions containing such compounds, which modulate the activity of store-operated calcium (SOC) channels. Also described herein are methods of using such SOC channel modulators, alone and in combination with other compounds, for treating diseases or conditions that would benefit from inhibition of SOC channel activity.
1. A method for treating an autoimmune disease or inflammatory disease in a mammal comprising administering to the mammal a compound having the structure of Formula (III):
wherein:
R″ 1 is
L 2 is —NH—C(═O)—, or —C(═O)NH—;
R 2 is phenyl or pyridyl; wherein phenyl or pyridyl is optionally substituted with at least one R 3 ;
R 3 is independently selected from F, Cl, Br, I, —CN, —NO 2 , —OH, —OCF 3 , —OR 5 , and —N(R 5 ) 2 ;
n is an integer selected from 1-4;
each R 5 is independently selected from C 1 -C 6 alkyl, and C 1 -C 6 haloalkyl;
R 7 is C 1 -C 6 alkyl; and
R 6 is selected from F, Cl, Br, I, —CN, —NO 2 , —OH, —CF 3 , —OCF 3 , —OR 5 , C 1 -C 6 alkyl, C 3 -C 8 cycloalkyl, and C 1 -C 6 haloalkyl;
or a pharmaceutically acceptable salt or pharmaceutically acceptable solvate thereof.
2. The method of claim 1 having the structure of Formula (IIIA):
3. The method of claim 2 wherein L 2 is —NH—C(═O)—.
4. The method of claim 3 wherein R 2 is phenyl.
5. The method of claim 4 wherein the phenyl group is substituted with at least one R 3 selected from F, Cl, Br, I, —CN, —OH, —OCF 3 , —OR 5 , and —N(R 5 ) 2 .
6. The method of claim 5 wherein R 6 is selected from —CF 3 , —OCF 3 , —OR 5 , C 1 -C 6 alkyl, and C 3 -C 8 cycloalkyl.
7. The method of claim 6 wherein R 6 is —CF 3 and R 7 is —CH 3 .
8. The method of claim 6 wherein R 6 is —CF 3 and R 7 is —CH 2 CH 3 .
9. The method of claim 5 wherein n is 1.
10. The method of claim 9 wherein R 3 is fluorine.
11. The method of claim 5 wherein phenyl is substituted with at least 2 F substituents.
12. The method of claim 5 wherein phenyl is substituted with at least 3 F substituents.
13. The method of claim 3 wherein R 2 is pyridyl.
14. The method of claim 13 wherein pyridyl is substituted with at least one R 3 selected from F, Cl, Br, —OH, —CN, —OCF 3 , —OR 5 , and —N(R 5 ) 2 .
15. The method of claim 14 wherein pyridyl is substituted with at least one fluorine.