Conjugated antisense compounds and their use
View Patent ↗Provided herein are oligomeric compounds with conjugate groups. In certain embodiments, the oligomeric compounds are conjugated to N-Acetylgalactosamine.
1. A compound having the formula (XXVI):
wherein:
T 2 is a group comprising a nucleoside, a nucleotide, a monomeric subunit, a reactive ester, a linker, a cleavable moiety or an oligomeric compound.
2. The compound of claim 1 , wherein the linker comprises an amine, an amide, an ester, an ether, a pyrrolidine, PEG, a polyamide, or a disulfide bond.
3. The compound of claim 1 , wherein the linker does not comprise a pyrrolidine.
4. The compound of claim 1 , wherein the linker has the formula:
5. The compound of claim 1 , wherein T 2 has the formula:
wherein:
CM is a cleavable moiety and T 3 is a nucleoside, a nucleotide, a monomeric subunit, or an oligomeric compound.
6. The compound of claim 1 , wherein T 2 has the formula:
wherein:
T 3 is a nucleoside, a nucleotide, a monomeric subunit, or an oligomeric compound.