Cataract removal using ultra-short pulse lasers
View Patent ↗A system and method of replacing a lens to treat a cataract is disclosed. Cataractous tissue is ablated via a multi-photon process using focused, ultra-short laser pulses. Multi-photon ablation requires an energy intensity between 10 13 to 10 15 W/cm 2 . Using lasers having femto-second duration pulses, this intensity is achieved with 50 micro-Joules of energy, allowing material disruption with very little heating or shock. The multi-photon ablated material is removed through a micro-channel that leads from the multi-photon ablated region to at least the surface of the eye. Once the material is removed a pre-polymer fluid is injected in to fill the void. This polymerizes into a gel once inside the lens. The polymerized, transformed material matches both the transparency to visible light and the Young's modulus of healthy lens.
1. A method of replacing all or part of a mammalian lens in a mammalian eye, comprising:
focusing a plurality of ultra-short laser pulses to a focal region within said mammalian lens, each of said ultra-short pulses having a pulse energy in a range of 10-100 μJ and focused to spot diameter in a range of 10-100 μm, creating a pulse intensity within said focal region in a range of 10 13 to 10 15 W/cm 2 , thereby creating a multi-photon ablated region of lens tissue in a vicinity of said focal region;
removing said multi-photon ablated lens tissue from said lens via a first micro-channel extending from a vicinity of said focal region to at least the surface of said mammalian eye thereby creating a multi-photon ablated cavity within said mammalian lens;
injecting a transformable material into said cavity within said lens via a second micro-channel extending from at least said surface of said mammalian eye; and
transforming said transformable material, once inside said cavity, to a replacement material having physical and optical properties that substantially match the functional physical and optical properties of a lens of a healthy mammalian eye.
2. The method of claim 1 wherein said replacement material has a Young's modulus in a range of 0.1-20 kPa and a refractive index for visible light in a range of 1.35 to 1.5.
3. The method of claim 2 wherein said transformable material comprises a plurality of monomer molecules and wherein said transformation comprises polymerization of said monomer molecules into a plurality of polymer molecules.
4. The method of claim 3 wherein said transformable material further comprises a catalyst and said polymerization occurs at a temperature in a vicinity of 98.6 F.
5. The method of claim 4 wherein said transformable material comprises a vinyl-containing polyorganosiloxane component, an organosilcon component and wherein said catalyst is a platinum metal containing component, and wherein said replacement material comprises a resultant, optically clear, biocompatible polymer.
6. The method of claim 1 wherein said spot diameter is less than or equal to 10 μm and said replacement material has a Young's modulus in a range of 0.5-5 kPa and a refractive index for visible light in a range of 1.38-1.42.
7. The method of claim 1 wherein said ultra-short laser pulses have a pulse duration of less than 10 psec.
8. The method of claim 7 wherein said ultra-short laser pulses travel toward said focal region along at least two distinct paths.
9. The method of claim 8 wherein said first micro-channel comprises a gauge 27 or higher hollow needle comprised of one of stainless steel or glass, or a combination thereof.
10. The method of claim 9 wherein removing said multi-photon ablated material further comprises functionally attaching a syringe to said hollow needle in a vicinity of an end of said hollow needle furthest from said cavity; and decreasing a pressure within said syringe thereby removing said multi-photon ablated material.
11. The method of claim 8 wherein said second micro-channel comprises a gauge 27 or higher hollow needle comprised of one of stainless steel or glass, or a combination thereof.
12. The method of claim 8 wherein said first and second micro-channels are the same micro-channel.
13. The method of claim 8 wherein said first micro-channel is created using said ultra-short laser pulses.
14. The method of claim 8 further comprising at least two beams of continuous wave, visible spectrum, laser light each of which follows one of said at least two distinct paths travelled by said ultra-short laser pulses.
15. The method of claim 8 wherein said directions of said paths are substantially normal to the surface of the eye at the point of crossing said surface.
16. The method of claim 1 wherein said ultra-short laser pulses have a pulse duration of less than 300 fsec.
17. The method of claim 1 wherein a location of said focal region is determined by automated control of at least one focusing optical lens.
18. The method of claim 1 further comprising the steps of:
observing, by a care-giver, the focal region using an optical microscope; and
automatically adjusting a position of said focal region by adjusting a position of a focusing optical lens determining a location of said focal region by an automated control unit using control feedback obtained via the use of said optical microscope.