IP Library › Granted Patent US 10,004,777
Granted Patent B2
US 10,004,777 · App. 14/270,852 · Granted Jun 26, 2018

Bioactive compositions from

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Quick Facts
Patent No.
US 10,004,777
App. No.
14/270,852
Granted
Jun 26, 2018
Kind
B2
Abstract

The present invention relates to isolated bioactive compositions containing bioactive fractions derived from Theacea plants. The present invention also relates to bioactive topical formulations containing the bioactive compositions. The present invention further relates to methods of using the bioactive compositions of the present invention, including, for example, methods for inhibiting inflammatory activity in skin tissue of a mammal, for protecting skin tissue of a mammal from ultraviolet light-induced damage, and for normalizing skin disorders in skin tissue of a mammal. The present invention also relates to methods for isolating bioactive fractions derived from cell juice or a cell walls component a Theacea plant.

Claims (14)

1. A method for isolating a bioactive fraction derived from a cell walls component of a Eurya plant, said method comprising:

providing a Eurya plant;

separating the Eurya plant into cell juice and a cell walls component;

treating the cell walls component under conditions effective to yield a bioactive fraction; and

isolating the bioactive fraction from the treated cell walls component,

wherein the Eurya plant is a Eurya sandwicensis plant.

2. The method according to claim 1 , wherein said bioactive fraction is a cell walls fraction.

3. The method according to claim 1 , wherein said bioactive fraction is a cell walls fraction extract.

4. The method according to claim 3 , wherein said cell walls fraction extract has a total catechin content of between about 2.1 and about 4.5milligrams per gram of dry matter.

5. The method according to claim 3 , wherein said cell walls fraction extract has a catechin content profile comprising:

between about 2.0 and about 3.0 milligrams of (+)-catechin per gram of dry matter of the cell walls fraction extract,

between about 0.005 and about 0.02 milligrams of (−)-epicatechin per gram of dry matter of the cell walls fraction extract,

between about 0.005 and about 0.02 milligrams of (−)-epigallocatechin gallate per gram of dry matter of the cell walls fraction extract, and

between about 0.003 and about 0.01 milligrams of (−)-epicatechin gallate per gram of dry matter of the cell walls fraction extract.

Assignments (5)
RELEASE OF SECURITY INTEREST Recorded Jan 10, 2020
From: THE BANK OF NOVA SCOTIA
To: AVOCA LLC; HERCULES LLC; ISP INVESTMENTS LLC; PHARMACHEM LABORATORIES LLC
Reel/Frame 051557/0504 →
SECURITY AGREEMENT Recorded Jul 3, 2017
From: AVOCA, INC.; HERCULES LLC; ISP INVESTMENTS LLC; PHARMACHEM LABORATORIES, INC.
To: THE BANK OF NOVA SCOTIA, AS ADMINISTRATIVE AGENT
Reel/Frame 043084/0753 →
CHANGE OF NAME Recorded May 24, 2017
From: ISP INVESTMENTS INC.
To: ISP INVESTMENTS LLC
Reel/Frame 042560/0842 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Sep 16, 2015
From: AKZO NOBEL SURFACE CHEMISTRY LLC; AKZO NOBEL CHEMICALS INTERNATIONA B.V.
To: ISP INVESTMENTS INC.
Reel/Frame 036583/0320 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Jun 26, 2014
From: KOGANOV, MICHAEL
To: AKZO NOBEL SURFACE CHEMISTRY LLC
Reel/Frame 033189/0146 →