Methods of treating gastrointestinal spasms triggered by stress
Methods of treating gastrointestinal spasms are provided. For example, methods of treating gastrointestinal spasms are provided, such methods not requiring the use of systemic drugs that have shown to (i) provide slow relief, (ii) cause adverse side effects, (iii) limit activities, (iv) worsen existing gastrointestinal conditions, (v) be unrecommended in several gastrointestinal conditions that include gastrointestinal spasms, or (vi) be unrecommended in the absence of diarrhea.
1. A method of treating a gastrointestinal spasm triggered by stress in a subject, the method comprising:
administering an effective amount of a composition to a subject having a gastrointestinal spasm triggered by stress, the composition having a water soluble polyphenol that was (i) water-extracted from a mixture of pomegranate husk and green tea leaf and (ii) combined with hydrogen peroxide prior to the administering;
wherein,
the hydrogen peroxide concentration ranges from about 0.001% to about 2.0% based on total dry weight of the composition;
the polyphenol comprises a tannin;
the polyphenol has a molecular weight ranging from about 170 Daltons to about 4000 Daltons; and,
the composition relieves a gastrointestinal spasm triggered by stress in the subject when compared to second subject in a control group also having a gastrointestinal spasm triggered by stress in which the composition was not administered.
2. The method of claim 1 , wherein the hydrogen peroxide concentration ranges from about 0.001% to about 1.5% based on total dry weight of the composition.
3. The method of claim 1 , wherein the hydrogen peroxide concentration ranges from about 0.001% to about 1.0% based on total dry weight of the composition.
4. The method of claim 1 , wherein the relief of the spasm is measured using a response selected from the group consisting of a reduction in abdominal pain, a reduction in bloating, a reduction in forceful defecation, a reduction in forceful vomiting, a reduction in defecation urgency, a reduction in constipation, and a reduction in incontinence.
5. The method of claim 1 , wherein the polyphenol comprises a hydrolysable tannin.
6. The method of claim 1 , wherein the polyphenol comprises a water soluble condensed tannin.
7. The method of claim 1 , wherein the polyphenol comprises a combination of a hydrolysable tannin and a water soluble condensed tannin.
8. The method of claim 1 , wherein the polyphenol comprises a flavanol.
9. The method of claim 1 , wherein the polyphenol comprises a catechin.
10. The method of claim 1 , wherein the polyphenol comprises gallic acid, epigallic acid, or a combination thereof.
11. The method of claim 1 , wherein the composition is administered in combination with an oral rehydration solution.
12. The method of claim 1 , wherein the polyphenol an ellagitannin and a gallotannin.
13. The method of claim 1 , wherein the polyphenol includes a punicalagin.
14. A method of treating a gastrointestinal spasm triggered by stress in a subject, comprising:
administering an effective amount of a composition to a subject having a gastrointestinal spasm triggered by stress, the composition produced from a process including
extracting a water soluble polyphenol from a combination of green tea leaf and pomegranate husk;
combining the polyphenol with hydrogen peroxide prior to the administering; wherein, the polyphenol has a molecular weight ranging from about 170 Daltons to about 4000 Daltons;
selecting a desired concentration for the composition; and,
diluting the composition to the desired concentration for the administering;
wherein,
the hydrogen peroxide concentration ranges from about 0.001% to about 2.0% based on total dry weight of the composition;
the polyphenol comprises a tannin; and,
the composition relieves a gastrointestinal spasm triggered by stress in the subject when compared to a second subject in a control group also having a gastrointestinal spasm triggered by stress in which the composition was not administered.
15. The method of claim 14 , wherein the hydrogen peroxide concentration ranges from about 0.001% to about 1.5% based on total dry weight of the composition.
16. The method of claim 14 , wherein the hydrogen peroxide concentration ranges from about 0.001% to about 1.0% based on total dry weight of the composition.
17. The method of claim 14 , wherein the relief of the spasm is measured using a response selected from the group consisting of a reduction in abdominal pain, a reduction in bloating, a reduction in forceful defecation, a reduction in forceful vomiting, a reduction in defecation urgency, a reduction in constipation, and a reduction in incontinence.
18. The method of claim 14 , wherein the polyphenol comprises a hydrolysable tannin.
19. The method of claim 14 , wherein the polyphenol comprises a water soluble condensed tannin.
20. The method of claim 14 , wherein the polyphenol comprises a combination of a hydrolysable tannin and a water soluble condensed tannin.
21. The method of claim 14 , wherein the polyphenol comprises a flavanol.
22. The method of claim 14 , wherein the polyphenol comprises a catechin.
23. The method of claim 14 , wherein the polyphenol comprises gallic acid, epigallic acid, or a combination thereof.
24. The method of claim 14 , wherein the polyphenol includes an ellagitannin and a gallotannin.
25. The method of claim 14 , wherein the polyphenol includes a punicalagin.
26. A method of treating a gastrointestinal spasm triggered by stress in a subject, comprising:
administering an effective amount of a composition to a subject having a gastrointestinal spasm triggered by stress, the composition produced from a process including
obtaining a water extract from a green tea leaf and a water extract from a pomegranate husk;
combining the water extract from the green tea leaf and the water extract from the pomegranate husk to form a mixture of polyphenols having a molecular weight ranging from about 170 Daltons to about 4000 Daltons; and,
adding hydrogen peroxide to the polyphenol prior to the administering, the hydrogen peroxide concentration selected from a group consisting of concentration ranges from about 0.001% to about 2.0%, from about 0.001% to about 1.5%, from about 0.001% to about 1.0%, and from about 0.001% to about 0.1%, each range based on total dry weight of the composition;
wherein,
the polyphenol comprises a tannin; and,
the composition relieves a gastrointestinal spasm triggered by stress in the subject when compared to the baseline health of the subject prior to the administering.