Composition and methods for modulating cell proliferation and cell death
View Patent ↗Described herein are compositions and methods for modulation of p53-dependent cell death and cell proliferation. The compositions are microRNAs and associated nucleic acids.
1. A method of treating a cancer associated with the p53 gene in a subject, comprising administering to a subject in need thereof an effective amount of a composition comprising a nucleic acid, wherein the nucleic acid comprises SEQ ID NO: 1or a sequence at least about 80% identical to SEQ ID NO: 1.
2. The method of claim 1 , wherein the composition is administered in combination with at least one other anticancer agent in unit dosage form.
3. The method of claim 1 , wherein said cancer is p53 negative.
4. A method of inducing tumor cell death or inhibiting tumor cell proliferation in a subject, comprising administering to a subject in need thereof a therapeutically effective amount of a composition comprising a nucleic acid, wherein the nucleic acid comprises SEQ ID NO: 1 or a sequence at least about 80% identical to SEQ ID NO: 1.
5. The method of claim 4 , wherein said tumor cells are p53 negative.