IP Library › Granted Patent US 9,637,546
Granted Patent B2
US 9,637,546 · App. 14/282,319 · Granted May 2, 2017

PD-1 antibodies and PD-L1 antibodies and uses thereof

Inventors: Daniel Olive (Marseilles, FR); Nacer-Eddine Serriari (Amiens, FR); Jacques Nunes (Marseilles, FR); Marguerite Ghiotto (Marseilles, FR)
C07K16/2896C07K16/2827A61K2039/505C07K2317/55C07K2317/74C07K2317/76C07K2317/92C07K2319/30
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Quick Facts
Patent No.
US 9,637,546
App. No.
14/282,319
Granted
May 2, 2017
Kind
B2
Abstract

The invention relates to PD-1 antibodies and PD-L1 antibodies and uses thereof.

Claims (5)

1. A PD-1 antibody obtainable from the hybridoma accessible under CNCM deposit number I-4122 or a derivative thereof having the same CDRs as the PD-1 antibody obtainable from the hybridoma accessible under CNCM deposit number I-4122.

2. A method of blocking the activity of PD-1 in a cell comprising contacting said cell with a PD-1 antibody according to claim 1 , wherein said PD-1 antibody blocks the interaction of said PD-1 with PD-L1.

3. A method of blocking the activity of PD-1 in a cell comprising contacting said cell with a PD-1 antibody according to claim 1 , wherein said PD-1 antibody blocks the interaction of said PD-1 with PD-L2.

4. The method of claim 2 wherein said cell is in a human or animal subject.

5. The method of claim 3 wherein said cell is in a human or animal subject.

Assignments (8)
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Jan 25, 2016
From: SERRIARI, NACER-EDDINE; NUNES, JACQUES; GHIOTTO, MARGUERITE
To: INSTITUT PAOLI CALMETTES; INSERM (INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE); UNIVERSITE D'AIX MARSEILLE
Reel/Frame 037574/0448 →
CORRECTIVE ASSIGNMENT TO CORRECT THE RECEIVING PARTY DATA PREVIOUSLY RECORDED AT REEL: 034958 FRAME: 0484. ASSIGNOR(S) HEREBY CONFIRMS THE ASSIGNMENT. Recorded Jul 28, 2015
From: UNIVERSITE D'AIX MARSEILLE; INSERM (INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE)
To: INSTITUT PAOLI CALMETTES; INSERM (INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE); UNIVERSITE D'AIX MARSEILLE
Reel/Frame 036692/0243 →
CORRECTIVE ASSIGNMENT TO CORRECT THE RECEIVING PARTY DATA PREVIOUSLY RECORDED AT REEL: 034966 FRAME: 0452. ASSIGNOR(S) HEREBY CONFIRMS THE ASSIGNMENT. Recorded Jul 28, 2015
From: UNIVERSITE D'AIX MARSEILLE; INSERM (INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE)
To: INSTITUT PAOLI CALMETTES; INSERM (INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE); UNIVERSITE D'AIX MARSEILLE
Reel/Frame 036692/0291 →
CORRECTIVE ASSIGNMENT TO CORRECT THE ASSIGNEE NAME PREVIOUSLY RECORDED AT REEL: 034966 FRAME: 0452. ASSIGNOR(S) HEREBY CONFIRMS THE ASSIGNMENT. Recorded Mar 11, 2015
From: UNIVERSITE D'AIX-MARSEILLE
To: INSTITUT PAOLI CALMETTES
Reel/Frame 035177/0965 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Feb 16, 2015
From: UNIVERSITE D'AIX-MARSEILLE
To: INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE; INSTITUT PAOLI CALMETTES
Reel/Frame 034966/0452 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Feb 13, 2015
From: INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE
To: INSTITUT PAOLI CALMETTES
Reel/Frame 034958/0484 →
MERGER Recorded Nov 20, 2014
From: UNIVERSITE DE LA MEDITERRANEE
To: UNIVERSITE D'AIX MARSEILLE
Reel/Frame 034220/0207 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Aug 5, 2014
From: OLIVE, DANIEL
To: UNIVERSITE DE LA MEDITERRANEE; INSERM (INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE)
Reel/Frame 033463/0126 →
Priority Claims (1)
EP 09305119 · Feb 9, 2010 · regional
Continuity (2)
Division 13148420
Related Publication 20140335093A1 · Nov 13, 2014