Compositions, devices, and methods for nicotine aerosol delivery
The present disclosure generally relates to compositions, and related devices and methods, useful in vaporizing devices such as electronic cigarettes. The composition may comprise nicotine, at least one solvent, and at least one ion pairing agent, and may be vaporized to form a condensation aerosol, wherein inhalation of the aerosol allows for deposition of nicotine with the respiratory system, including deep lung deposition. The vaporizing device may comprise a vaporization unit, a battery, and an integrated circuit coupled to the battery, wherein the integrated circuit is configured to control the battery for rapid initial vaporization without overheating, producing thermal degradation products, or draining battery energy. The battery may operate with pulse width modulation for at least a portion of the time the vaporizing device is being used.
1. A liquid composition comprising nicotine, at least one solvent, and at least one ion pairing agent comprising lactic acid;
wherein the lactic acid has a molar ratio with respect to nicotine ranging from about 2:3 to about 1:1; and
wherein vaporization and condensation of the composition with an electronic cigarette comprising a battery and a heating element, produces an aerosol having a gas phase and a particulate phase;
wherein at least 85% of the nicotine by weight in the aerosol is partitioned into the particulate phase;
wherein a pH of the composition is within a range of about pH 7 to about pH 8; and
wherein the at least one solvent comprises from about 44% to about 48% glycerol and from about 44% to about 48% propylene glycol by weight with respect to the total weight of the composition.
2. The composition of claim 1 , wherein the nicotine is not in free base form.
3. The composition of claim 1 , wherein a pH of the aerosol is ±0.3 pH of the pH of the composition.
4. The composition of claim 1 , further comprising at least one agent chosen from menthol, a tobacco alkaloid compound, a preservative, or a combination thereof, wherein the at least one agent has a molar ratio with respect to nicotine ranging from about 1:200 to about 1:2.
5. The composition of claim 1 , comprising from about 1.5% to about 6.0% nicotine.
6. The composition of claim 5 , further comprising from about 0.1% to about 3.0% of at least one agent chosen from menthol, a tobacco alkaloid compound, a non-tobacco flavor, or a combination thereof, by weight with respect to the total weight of the composition.
7. A liquid composition comprising nicotine, at least one solvent, and at least one ion pairing agent comprising lactic acid,
wherein the lactic acid has a molar ratio with respect to nicotine of about 5:6,
wherein vaporization and condensation of the composition with an electronic cigarette comprising a battery and a heating element produces an aerosol having a gas phase and a particulate phase,
wherein at least 85% of the nicotine by weight in the aerosol is partitioned into the particulate phase,
wherein a pH of the composition is within a range of about pH 7 to about pH 8; and
wherein the at least one solvent comprises from about 44% to about 48% glycerol and from about 44% to about 48% propylene glycol by weight with respect to the total weight of the composition.
8. A liquid composition comprising nicotine, at least one solvent, at least one ion pairing agent comprising lactic acid, and at least one agent chosen from chosen from menthol, a tobacco alkaloid compound, a non-tobacco flavor, or a combination thereof;
wherein the lactic acid has a molar ratio with respect to nicotine ranging from about 2:3 to about 1:1, and the at least one agent has a molar ratio with respect to nicotine ranging from about 1:200 to about 1:2;
wherein vaporization and condensation of the composition with an electronic cigarette comprising a battery and a heating element produces an aerosol having a gas phase and a particulate phase;
wherein at least 85% of the nicotine by weight in the aerosol to be partitioned into the particulate phase;
wherein a pH of the composition is within a range of about pH 7 to about pH 8; and
wherein the at least one solvent comprises from about 44% to about 48% glycerol and from about 44% to about 48% propylene glycol by weight with respect to the total weight of the composition.
9. The composition of claim 1 , wherein the composition comprises about 6.0% nicotine by weight with respect to the total weight of the composition.
10. The composition of claim 4 , wherein the composition comprises less than about 2% by weight of the at least one agent.
11. The composition of claim 7 , further comprising about 0.1% to about 3.0% of at least one agent chosen from menthol, a tobacco alkaloid compound, a non-tobacco flavor, or a combination thereof, by weight with respect to the total weight of the composition.
12. The composition of claim 7 , wherein the composition comprises about 4.5% or about 6.0% nicotine by weight with respect to the total weight of the composition.
13. The composition of claim 7 , wherein the composition comprises about 1.0% or about 1.5% nicotine by weight with respect to the total weight of the composition.
14. The composition of claim 8 , wherein the at least one agent comprises menthol, at least one tobacco alkaloid chosen from nornicotine, myosmine, anabasine, nicotyrine, metanicotine, anatabine, nornicotyrine, or continine, or a combination thereof.
15. The composition of claim 8 , wherein the at least one agent comprises menthol, and the molar ratio of menthol to nicotine is about 1:100 to about 1:50.
16. The composition of claim 8 , wherein the molar ratio of lactic acid to nicotine ranges from about 3:4 to about 5:6.
17. A composition comprising:
from about 1.5% to about 6.0% nicotine by weight with respect to the total weight of the composition;
lactic acid, wherein a molar ratio of the lactic acid with respect to nicotine ranges from about 2:3 to about 1:1;
at least one agent chosen from menthol, a tobacco alkaloid compound, a non-tobacco flavor, or a combination thereof, the at least one agent having a molar ratio relative to nicotine of about 1:50 to about 1:400; and
at least one solvent comprising from about 44% to about 48% glycerol and from about 44% to about 48% propylene glycol by weight with respect to the total weight of the composition;
wherein vaporization and condensation of the composition with an electronic cigarette comprising a battery and a heating element produces an aerosol having a gas phase and a particulate phase;
wherein at least 85% of the nicotine by weight in the aerosol is partitioned into the particulate phase; and
wherein a pH of the composition is within a range of about pH 7 to about pH 8.
18. The method of claim 1 , wherein the at least one solvent comprises about 45% glycerol and about 45% polyethylene glycol by weight with respect to the total weight of the composition.
19. The method of claim 7 , wherein the at least one solvent comprises about 45% glycerol and about 45% polyethylene glycol by weight with respect to the total weight of the composition.
20. The method of claim 8 , wherein the at least one solvent comprises about 45% glycerol and about 45% polyethylene glycol by weight with respect to the total weight of the composition.
21. The method of claim 17 , wherein the at least one solvent comprises about 45% glycerol and about 45% polyethylene glycol by weight with respect to the total weight of the composition.