Connective-tissue-based or dermal-tissue-based grafts/implants
View Patent ↗The present invention is directed to a composition comprising a matrix suitable for implantation in humans, comprising defatted, shredded, allogeneic human muscle tissue that has been combined with an aqueous carrier and dried in a predetermined shape. Also disclosed is a tissue graft or implant comprising a matrix suitable for implantation in humans, comprising defatted, shredded, allogeneic human muscle tissue that has been combined with an aqueous carrier and dried in a predetermined shape. The composition and/or tissue graft or implant of the invention is usable in combination with seeded cells, a tissue growth factor, and/or a chemotactic gent to attract a desired cell.
1. An implant comprising:
a matrix of allogeneic or xenogenic tissue formed from a tissue slurry that has been dried to a shape, either wherein the shape includes a cavity, a pouch, or a hole, or wherein the implant further comprises a post, a hook, or a suture, and wherein said implant has the property of holding said shape during rehydration and handling.
2. The implant of claim 1 , wherein the tissue is tendon, fascia, ligament or dermis.
3. The implant of claim 1 , wherein said shape is selected from the group consisting of a strip, a sheet, a molded 3D shaped object, a sponge, and a gasket.
4. The implant of claim 3 wherein said shape is a molded 3D shape designed to fit into a particular anatomical feature or surgically created space.
5. The implant of claim 1 , wherein the implant further comprises seeded cells, a growth factor, a chemotactic agent, or a combination thereof.
6. The implant of claim 5 , wherein the implant comprises a growth factor suitable for inducing the growth of fibroblasts, melanocytes, osteogenic cells, stem cells, skin cells or a combination thereof.
7. The implant of claim 5 , wherein said implant comprises seeded cells that are fibroblasts, melanocytes, osteogenic cells, stem cells, skin cells or a combination thereof.
8. The implant of claim 1 , which has a moisture content of 3% or less.
9. An implant comprising
a matrix of allogeneic or xenogenic tissue formed from a tissue slurry that has been dried to a shape and
particles of demineralized bone matrix (DBM), mineralized bone matrix, cortical cancellous chips (CCC), crushed cancellous chips, tricalcium phosphate, hydroxyapatite, or biphasic calcium phosphate dispersed in the matrix
wherein said implant has the property of holding said shape during rehydration and handling.
10. The implant of claim 9 , wherein the tissue is tendon, fascia, ligament or dermis.
11. The implant of claim 9 , wherein said shape is selected from the group consisting of a strip, a sheet, a molded 3D shaped object, a sponge, and a gasket.
12. The implant of claim 11 wherein said shape is a molded 3D shape designed to fit into a particular anatomical feature or surgically created space.
13. The implant of claim 9 , wherein the implant further comprises seeded cells, a growth factor, a chemotactic agent, or a combination thereof.
14. The implant of claim 13 , wherein the implant comprises a growth factor suitable for inducing the growth of fibroblasts, melanocytes, osteogenic cells, stem cells, skin cells or a combination thereof.
15. The implant of claim 13 , wherein said implant comprises seeded cells that are fibroblasts, melanocytes, osteogenic cells, stem cells, skin cells or a combination thereof.
16. The implant of claim 9 , which has a moisture content of 3% or less.
17. An implant comprising
a matrix of allogeneic or xenogenic tissue formed from a tissue slurry that has been dried to a strip shape
wherein said implant has the property of holding said shape during rehydration and handling.
18. The implant of claim 17 , wherein the tissue is tendon, fascia, ligament or dermis.
19. The implant of claim 17 , wherein strip has dimensions of about 10 mm to 500 mm long, by 10 mm to 200 mm wide and 1 mm to 10 mm thick.
20. The implant of claim 19 , wherein said strip has dimensions of about 50 mm to 90 mm long by 15 mm to 35 mm wide and 2 mm to 5 mm thick.
21. The implant of claim 17 , wherein said strip has a cross section of a rectangle, square, triangle, other polygon, circle, half circle, ellipse, or partial ellipse.
22. The implant of claim 17 , wherein the implant further comprises seeded cells, a growth factor, a chemotactic agent, or a combination thereof.
23. The implant of claim 22 , wherein the implant comprises a growth factor suitable for inducing the growth of fibroblasts, melanocytes, osteogenic cells, stem cells, skin cells or a combination thereof.
24. The implant of claim 22 , wherein said implant comprises seeded cells that are fibroblasts, melanocytes, osteogenic cells, stem cells, skin cells or a combination thereof.
25. The implant of claim 17 , which has a moisture content of 3% or less.
26. An implant comprising
a matrix of allogeneic or xenogenic tissue formed from a tissue slurry that has been dried to a disk shape having dimensions of about 10 mm to 100 mm diameter and 1 mm to 10 mm thick
wherein said implant has the property of holding said shape during rehydration and handling.
27. The implant of claim 26 , wherein the tissue is tendon, fascia, ligament or dermis.
28. The implant of claim 26 , wherein the implant further comprises seeded cells, a growth factor, a chemotactic agent, or a combination thereof.
29. The implant of claim 28 , wherein the implant comprises a growth factor suitable for inducing the growth of fibroblasts, melanocytes, osteogenic cells, stem cells, skin cells or a combination thereof.
30. The implant of claim 28 , wherein said implant comprises seeded cells that are fibroblasts, melanocytes, osteogenic cells, stem cells, skin cells or a combination thereof.
31. The implant of claim 26 , which has a moisture content of 3% or less.
32. An implant comprising
a matrix of allogeneic or xenogenic tissue formed from a tissue slurry that has been dried to a molded 3D shape having dimensions of about 100 mm by 100 mm and 25 mm thick
wherein said implant has the property of holding said shape during rehydration and handling.
33. The implant of claim 32 , wherein the tissue is tendon, fascia, ligament or dermis.
34. An implant comprising a matrix of allogenic or xenogenic tissue formed from a tissue slurry that has been dried to a molded 3D shape having dimensions of about 50 mm by 70 mm and 20 mm thick, wherein said implant has the property of holding said shape during rehydration and handling.
35. An implant comprising a matrix of allogenic or xenogenic tissue formed from a tissue slurry that has been dried to a molded 3D shape having dimensions of about 30 mm by 50 mm and 15 mm thick, wherein said implant has the property of holding said shape during rehydration and handling.
36. The implant of claim 32 wherein said shape is a molded 3 D shape designed to fit into a particular anatomical feature or surgically created space.
37. The implant of claim 32 , wherein the implant further comprises seeded cells, a growth factor, a chemotactic agent, or a combination thereof.
38. The implant of claim 37 , wherein the implant comprises a growth factor suitable for inducing the growth of fibroblasts, melanocytes, osteogenic cells, stem cells, skin cells or a combination thereof.
39. The implant of claim 37 , wherein said implant comprises seeded cells that are fibroblasts, melanocytes, osteogenic cells, stem cells, skin cells or a combination thereof.
40. The implant of claim 32 , which has a moisture content of 3% or less.