AROMATIC-CATIONIC PEPTIDES AND USES OF SAME
The present disclosure provides aromatic-cationic peptide compositions and methods of using the same. The methods comprise use of the peptides in electron transport, inhibition of cardiolipin peroxidation, apoptosis inhibition and electrical conductance.
1 - 60 . (canceled)
61 . A method for treating polycystic kidney in a subject in need thereof, comprising:
administering to the subject an effective amount of an aromatic-cationic peptide having the formula D-Arg-2′6′-Dmt-Lys-Phe-NH 2 , Phe-D-Arg-Phe-Lys-NH 2 , or a pharmaceutically acceptable salt thereof.
62 . The method of claim 61 , wherein treatment comprises reducing one or more symptoms of polycystic kidney.
63 . The method of claim 62 , wherein the one or more symptoms comprise an increase in kidney cell apoptosis and cytosolic cytochrome c in kidney cells.
64 . The method of claim 61 , wherein the peptide has the formula D-Arg-2′6′-Dmt-Lys-Phe-NH 2 .
65 . The method of claim 61 , wherein the peptide has the formula Phe-D-Arg-Phe-Lys-NH 2 .
66 . The method of claim 61 , wherein the subject is a human.
67 . The method of claim 61 , wherein the peptide is administered orally, topically, intranasally, intraperitoneally, intravenously, subcutaneously, intramuscularly, or iontophoretically.