MICRONIZED PLACENTAL TISSUE COMPOSITIONS AND METHODS OF MAKING AND USING THE SAME
Described herein are compositions composed of micronized placental components, extracts of micronized placental components, and pharmaceutical compositions thereof. The compositions have numerous medical applications. Methods for making and using the micronized compositions and the extracts thereof are also described herein.
1 . A pharmaceutical composition comprising micronized placental tissue having a particle size of less than 100 μm and selected from the group consisting of amnion, chorion, intermediate tissue layer, or any combination thereof.
2 . The composition of claim 1 , wherein the micronized placental tissue has a particle size between 50 μm and 100 μm.
3 . The composition of claim 1 , wherein the micronized placental tissue has a maximum particle size greater than 25 μm, but less than 75 μm.
4 . A pharmaceutical composition comprising micronized amnion having a particle size less than 75 μm and intermediate tissue layer as individual components, wherein the intermediate tissue layer has been removed from the amnion.
5 . The composition of claim 4 , wherein the micronized amnion has a maximum particle size greater than 25 μm, but less than 75 μm.
6 . The composition of claim 1 , wherein the weight ratio of amnion to intermediate tissue layer is from 10:1 to 1:10.
7 . The composition of claim 1 , wherein the weight ratio of amnion to intermediate tissue layer is from 2:1 to 1:1 and the micronized amnion and intermediate tissue layer has a particle size from 25 μm to 75 μm.
8 . The composition of claim 1 , wherein the composition further comprises a filler.
9 . The composition of claim 8 , wherein the filler comprises allograft pericardium, allograft acellular dermis, Wharton's jelly, purified xenograft Type-1 collagen, biocellulose polymers or copolymers, biocompatible synthetic polymer or copolymer films, purified small intestinal submucosa, bladder acellular matrix, cadaveric fascia, or any combination thereof.
10 . The composition of claim 1 , wherein the composition further comprises a pharmaceutically acceptable carrier.
11 . The composition of claim 10 , wherein the pharmaceutically acceptable carrier comprises water, aqueous hyaluronic acid, saline, Ringer's solution, dextrose solution, Hank's solution, a buffer, or a nonaqueous vehicle.
12 . The composition of claim 10 , wherein the composition is a liquid, gel, or paste.
13 . The composition of claim 10 , wherein the composition is injectable.
14 . The use of the composition of claim 1 as a dermal filler.