Drug combinations and uses in treating a coughing condition
View Patent ↗The present specification discloses compositions comprising a plurality of therapeutic compound having antitussive activity and methods and uses for treating a coughing condition with such compositions.
1. A pharmaceutical composition comprising 0.5 mg/mL to 10 mg/mL of Theobromine, 0.25 mg/mL to 5 mg/mL of Dextromethorphan, and 0.1 mg/mL to 5 mg/mL of Phenylephrine, wherein the pharmaceutical composition does not include an anti-histamine and wherein the therapeutically-effective amount of the theobromine is at most 250 mg/day.
2. The pharmaceutical composition according to claim 1 , wherein the composition comprises 0.5 mg/mL to 6 mg/mL of Theobromine, 0.5 mg/mL to 3 mg/mL of Dextromethorphan, and 0.1 mg/mL to 2 mg/mL of Phenylephrine.
3. The pharmaceutical composition according to claim 2 , wherein the composition comprises 1 mg/mL to 3 mg/mL of Theobromine, 1 mg/mL to 3 mg/mL of Dextromethorphan, and 0.1 mg/mL to 1 mg/mL of Phenylephrine.
4. The pharmaceutical composition according to claim 3 , wherein the composition comprises 2 mg/mL of Theobromine, 1 mg/mL of Dextromethorphan, and 0.5 mg/mL of Phenylephrine.
5. A method of treating cough, the method comprising the step of administering a therapeutically-effective amount of the pharmaceutical composition of claim 1 .
6. The method according to claim 5 , wherein the composition comprises 0.5 mg/mL to 6 mg/mL of Theobromine, 0.5 mg/mL to 3 mg/mL of Dextromethorphan, and 0.1 mg/mL to 2 mg/mL of Phenylephrine.
7. The method according to claim 6 , wherein the composition comprises 1 mg/mL to 3 mg/mL of Theobromine, 1 mg/mL to 3 mg/mL of Dextromethorphan, and 0.1 mg/mL to 1 mg/mL of Phenylephrine.
8. The method according to claim 7 , wherein the composition comprises 2 mg/mL of Theobromine, 1 mg/mL of Dextromethorphan, and 0.5 mg/mL of Phenylephrine.
9. The method according to claim 5 , wherein the therapeutically-effective amount of the pharmaceutical composition comprises between 40 mg/day and 300 mg/day of Theobromine, 10 mg/day and 150 mg/day of Dextromethorphan, and 5 mg/day and 75 mg/day of Phenylephrine.
10. The method according to claim 9 , wherein the therapeutically-effective amount of the pharmaceutical composition comprises between 60 mg/day and 240 mg/day of Theobromine, 30 mg/day and 120 mg/day of Dextromethorphan, and 15 mg/day and 60 mg/day of Phenylephrine.