BIOMEDICAL DEVICES
The present invention provides a biomedical device comprising a porous hydrophilic substrate; a hydrophobic material; a fluid inlet; two or more test zones, wherein fluid vertically flows through the porous hydrophilic substrate and then distributes into the test zones. The present invention further provides a method for making a biomedical device.
1 . A biomedical device comprising
a porous hydrophilic substrate;
a hydrophobic material,
wherein the hydrophobic material is applied to at least part of the porous hydrophilic substrate to form a hydrophobic barrier pattern;
a fluid inlet, which is located on the surface of the porous hydrophilic substrate;
two or more test zones, which are positioned on another surface of the porous hydrophilic substrate and comprise bioassay reagents;
wherein the fluid vertically flows through the porous hydrophilic substrate and is distributed to said test zones.
2 . The biomedical device of claim 1 , wherein the hydrophobic material is a photocuring resin, thermosetting resin or thermoplastic resin.
3 . The biomedical device of claim 1 , wherein the hydrophobic material comprises a thermoplastic acrylate, photocuring acrylate, thermosetting silicone resin, thermoplastic epoxy resin or thermosetting epoxy resin.
4 . The biomedical device of claim 1 , wherein the hydrophobic material has resistance against water and organic solvents.
5 . The biomedical device of claim 1 , wherein the fluid inlet is defined by the hydrophobic barrier pattern on the surface of the porous hydrophilic substrate.
6 . The biomedical device of claim 1 , wherein the two or more test zones are defined by the hydrophobic barrier pattern on another surface of the porous hydrophilic substrate.
7 . The biomedical device of claim 1 , wherein the hydrophilic substrate is selected from a group comprising nitrocellulose acetate, cellulose acetate, cellulosic paper, filter paper, tissue paper, writing paper, cloth, porous polymer films and the combination thereof.
8 . The biomedical device of claim 1 , wherein the fluid inlet further comprises a hydrophilic paste.
9 . A method for making a biomedical device, comprising:
applying a hydrophobic material to at least part of a porous hydrophilic substrate to form a hydrophobic barrier pattern and outline a fluid inlet on the surface of the porous hydrophilic substrate;
forming two or more test zones on the other surface of the porous hydrophilic substrate; and
disposing bioassay reagents into the test zones.
10 . The method according to claim 9 , wherein the application of a hydrophobic material may be carried out by screen printing or inkjet printing.