Sugar chain-containing polymer, and sugar chain-containing polymer complex
A sugar chain-containing polymer that enables targeting to the lesion area of liver fibrosis and is useful for imaging, diagnosis and therapy of liver fibrosis; and a sugar chain-containing polymer complex comprising the polymer as a carrier for an anionic substance useful fix therapy and the like; are provided. The polymer is a sugar chain-containing polymer which is a cationic polymer comprising an amine, which polymer comprises N-acetylglucosamine bound thereto. The polymer preferably has a disulfide bond. The polymer preferably has a structure in which polyethyleneimine is linked via a disulfide bond.
1. A sugar chain-containing polymer comprising:
a polyethyleneimine with a disulfide bond located in the backbone of the polyethyleneamine; and a chemical structure extending from the backbone of the polyethyleneimine as shown below:
2. The sugar chain-containing polymer according to claim 1 , further comprising a fluorescent dye bound thereto.
3. The sugar chain-containing polymer according to claim 2 , wherein said fluorescent dye is indocyanine green.
4. A sugar chain-containing polymer complex comprising of the sugar chain-containing polymer according to claim 1 and an anionic substance(s).
5. The sugar chain-containing polymer complex according to claim 4 , wherein said sugar chain-containing polymer and said anionic substance(s) form a complex by electrostatic interaction.
6. The sugar chain-containing polymer complex according to claim 4 , wherein said anionic substance is nucleic acid.
7. The sugar chain-containing polymer complex according to claim 6 , wherein said nucleic acid is RNA.
8. The sugar chain-containing polymer complex according to claim 7 , wherein said RNA is an siRNA.
9. The sugar chain-containing polymer complex according to claim 8 , wherein said siRNA is an siRNA of TGFβ1.
10. A sugar chain-containing polymer complex comprising of the sugar chain-containing polymer according to claim 2 and an anionic substance(s).
11. A sugar chain-containing polymer complex comprising of the sugar chain-containing polymer according to claim 3 and an anionic substance(s).
12. The sugar chain-containing polymer complex according to claim 5 , wherein said anionic substance is nucleic acid.
13. The sugar chain-containing polymer complex according to claim 1 , wherein the disulfide bond is introduced into the polyethyleneimine backbone by reacting N,N′-cystaminebisacrylamide with polyethyleneimine.