Oligomer conjugates of heteropentacyclic nucleosides
View Patent ↗The invention provides small molecule drugs that are chemically modified by covalent attachment of a water-soluble oligomer.
1. A compound having the following structure
wherein n is between 1 and 30 (inclusive), and 5′-phosphates and 3′,5′-cyclic phosphates thereof and ammonium and alkali metal salts of each of the 5′-phosphates and 3′,5′-cyclic phosphates.
2. The compound of claim 1 , wherein n is 2.
3. The compound of claim 1 , wherein n is 3.
4. The compound of claim 1 , wherein n is 4.
5. The compound of claim 1 , wherein n is 5.
6. The compound of claim 1 , wherein n is 6.
7. The compound of claim 1 , wherein n is 7.
8. The compound of claim 1 , wherein n is 8.
9. The compound of claim 1 , wherein n is 9.
10. The compound of claim 1 , wherein n is 10.
11. The compound of claim 1 , wherein n is between 21 and 30.