Methods of sterilization and treating infection using irreversible electroporation
A method for treating an infection using irreversible electroporation is presented. The method includes providing an ablation device that has at least one electrode and inserting the ablation device into a target tissue of a patient. The tissue at least partially surrounds the implanted medical device. The outer surface of the medical device is at least partially covered by infectious cells. The method also involves positioning at least one electrode in or near the implanted medical device and delivering electrical pulses to or near the implanted medical device sufficient to irreversibly electroporate the infectious cells.
1. A method of treating an infection in patient, wherein the method comprises:
implanting an implanted medical device, wherein the implanted medical device is made of a conductive material and wherein the outer surface of the medical device is at least partially covered by infectious cells;
inserting an ablation device into a target tissue of the patient, the ablation device comprising at least one electrode, wherein the tissue at least partially surrounds the implanted medical device;
positioning the at least one electrode a pre-determined distance from the implanted medical device; and
delivering electrical pulses through the at least one electrode to or near the implanted medical device sufficient to irreversibly electroporate the infectious cells, the implanted medical device acting as a return electrode.
2. The method of claim 1 , wherein the implanted medical device is selected from the group comprising: a catheter, an artificial cartilaginous implant, a pacemaker, an implantable port, a stent, orthopedic prosthetic, PICC, implantable valve, spinal implant, tooth implant, and a filter.
3. The method of claim 1 , wherein the infectious cells comprise bacterial cells selected from the group comprising bacteremia, Staphylococcus epidermidis, Escherichia coli, Staphylococcus aureus, Streptococcus Mutans, Streptococcus Mitus, Streptococcus Salivarius , and Enterobacter Aerogenes.
4. A method of sterilizing an infected implanted medical device, wherein the method comprises:
implanting an implanted medical device, wherein the implanted medical device is made of a conductive material and wherein the outer surface of the medical device is at least partially covered by infectious cells;
inserting an ablation device into a target tissue of the patient, the ablation device comprising at least one electrode, wherein the tissue at least partially surrounds an implanted medical device and wherein the outer surface of the medical device is at least partially covered by infectious cells;
positioning the at least one electrode a pre-determined distance from the implanted medical device; and
delivering electrical pulses through the at least one electrode to or near the implanted medical device sufficient to irreversibly electroporate the infectious cells, thereby sterilizing the implanted medical device, the implanted medical device acting as a return electrode.
5. The method of claim 4 , wherein the implanted medical device is selected from the group comprising: a catheter, an artificial cartilaginous implant, a pacemaker, an implantable port, a stent, orthopedic prosthetic, PICC, implantable valve, spinal implant, tooth implant, and a filter.
6. The method of claim 4 , wherein the infectious cells comprise bacterial cells selected from the group comprising bacteremia, Staphylococcus epidermidis, Escherichia coli, Staphylococcus aureus, Streptococcus Mutans, Streptococcus Mitus, Streptococcus Salivarius , and Enterobacter Aerogenes.