Pharmaceutical formulations of xanthine or xanthine derivatives, and their use
View Patent ↗The present invention relates to pharmaceutical formulations comprising xanthine or xanthine derivatives, kits thereof, and methods for treating fibrotic diseases by local administration.
1. A method for treating Peyronie's disease in a subject in need thereof, comprising injecting into at least one of the corpus cavernosa of the penis of the subject a pharmaceutical formulation consisting essentially of a therapeutic effective amount of pentoxifylline or a pharmaceutically acceptable salt thereof, wherein the formulation is used as a mono therapy for treating Peyronie's disease.
2. The method of claim 1 , wherein the pharmaceutical formulation has a pH between 5.5 and 6.
3. The method of claim 1 , wherein the therapeutically effective amount is between 4 mg and 20 mg per day.
4. The method of claim 1 , wherein the pharmaceutical formulation is injected at the base of the penis about 2 cm from where the penis attaches to the abdomen.
5. The method of claim 1 , wherein at least one symptom of Peyronie's disease is improved.
6. The method of claim 5 , wherein the at least one symptom is pain.
7. The method of claim 5 , wherein the at least one symptom is penile curvature.
8. The method of claim 5 , wherein the at least one symptom is erectile dysfunction.
9. The method of claim 3 , wherein at least one symptom of Peyronie's disease is improved.
10. The method of claim 9 , wherein the at least one symptom is pain.
11. The method of claim 9 , wherein the at least one symptom is penile curvature.
12. The method of claim 9 , wherein the at least one symptom is erectile dysfunction.