IP Library › Granted Patent US 9,803,027
Granted Patent B2
US 9,803,027 · App. 14/308,936 · Granted Oct 31, 2017

Method for decreasing immunogenicity

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Quick Facts
Patent No.
US 9,803,027
App. No.
14/308,936
Granted
Oct 31, 2017
Kind
B2
Abstract

A method for decreasing the immunogenicity of antibody variable domains is disclosed.

Claims (2)

1. A single chain antibody (scFv), wherein the scFv comprises a variable light chain comprising a serine at position 101 (Aho numbering) and a variable heavy chain comprising Serine (S) at heavy chain amino acid position 12, Threonine (T) at heavy chain amino acid position 103, and Threonine (T) at heavy chain amino acid position 144 (AHo numbering).

2. A pharmaceutical composition comprising the scFv of claim 1 .

Assignments (1)
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Jan 26, 2024
From: ESBATECH, A NOVARTIS COMPANY LLC
To: NOVARTIS AG
Reel/Frame 066375/0001 →