Method for enhancing the bioavailability of ospemifene
View Patent ↗This invention relates to a method for enhancing the bioavailability of a therapeutically active compound of the formula (I) or a geometric isomer, a stereoisomer, a pharmaceutically acceptable salt, an ester thereof or a metabolite thereof, wherein said compound is administered orally to the individual in connection with the intake of food.
1. A method for enhancing the bioavailability of a therapeutically active compound of the formula (I)
or a geometric isomer, a stereoisomer, a pharmaceutically acceptable salt, an ester thereof or a metabolite thereof, wherein said compound is administered orally to an individual in connection with the intake of food.
2. The method according to claim 1 wherein compound (I) is ospemifene.
3. The method according to claim 1 wherein the compound is administered at a time point which is in the range defined by 1 hour before starting the food intake and 2 hours after starting the food intake.
4. The method according to claim 3 wherein the compound is administered at a time point which is in the range defined to begin at a time point during the food intake and to end 1 hour after the food intake was started.
5. The method according to claim 4 wherein the compound is administered at a time point which is no later than 0.5 hour after starting the food intake.
6. The method according to claim 1 wherein the food is any foodstuff of nutritional value being capable of causing secretion of bile acids.
7. The method according to claim 1 wherein the compound is used for treatment of osteoporosis.
8. The method according to claim 1 wherein the compound is used for treatment of symptoms related to skin atrophy, or to epithelial or mucosal atrophy.
9. The method according to claim 8 wherein the symptoms are urinary symptoms or vaginal symptoms.