IP Library › Patent Application 14315998
Patent Application
App. No. 14/315,998

OLIGOMER-CORTICOSTEROID CONJUGATES

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Quick Facts
Patent No.
US None
App. No.
14/315,998
Abstract

The invention provides corticosteroids that are chemically modified by covalent attachment of a water-soluble oligomer. A compound of the invention, when administered by any of a number of administration routes, exhibits different properties compared to the properties of the corticosteroid not attached to the water-soluble oligomer.

Claims (4)

1 . A compound comprising a corticosteroid residue covalently attached via a releasable linkage to a poly(ethylene oxide), wherein the corticosteroid residue is a residue dexamethasone and the poly(ethylene oxide) is branched.

2 . The compound of claim 1 , wherein the molecular weight of the poly(ethylene oxide) is below about 1500 Daltons.

3 . The compound of claim 1 , wherein the molecular weight of the poly(ethylene oxide) is below about 1300 Daltons.

4 . The compound of claim 1 , wherein the molecular weight of the poly(ethylene oxide) is below about 1000 Daltons.

Assignments (4)
RELEASE OF SECURITY INTEREST Recorded Apr 17, 2020
From: TC LENDING, LLC, AS COLLATERAL AGENT
To: NEKTAR THERAPEUTICS
Reel/Frame 053180/0009 →
RELEASE OF SECURITY INTEREST RECORDED AT REEL 33760, FRAME 0791 Recorded Oct 14, 2015
From: WELLS FARGO BANK, NATIONAL ASSOCIATION, AS COLLATERAL AGENT
To: NEKTAR THERAPEUTICS
Reel/Frame 036865/0265 →
GRANT OF SECURITY INTEREST IN UNITED STATES PATENTS Recorded Oct 6, 2015
From: NEKTAR THERAPEUTICS
To: TC LENDING, LLC, AS COLLATERAL AGENT
Reel/Frame 036796/0562 →
SECURITY INTEREST Recorded Sep 17, 2014
From: NEKTAR THERAPEUTICS
To: WELLS FARGO BANK, NATIONAL ASSOCIATION, AS COLLATERAL AGENT
Reel/Frame 033760/0791 →