IP Library › Patent Application 14316008
Patent Application
App. No. 14/316,008

Cyclooxygenase Inhibitor and Calcium Channel Antagonist Compositions and Methods for Use in Urological Procedures

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Quick Facts
Patent No.
US None
App. No.
14/316,008
Abstract

Compositions of a cyclooxygenase inhibitor and a calcium channel antagonist in a liquid carrier. The composition may be administered the urinary tract during urological diagnostic, interventional, surgical and other medical procedures. One disclosed composition comprises ketoprofen and nifedipine in a liquid irrigation carrier, and includes a solubilizing agent, stabilizing agents and a buffering agent.

Claims (7)

1 . A stable composition for us in inhibiting pain/inflammation and spasm, comprising a combination of ketoprofen, nifedipine, propyl gallate and sodium metabisulfite in a liquid carrier, wherein the ketoprofen and nifedipine are included at a ketoprofen to nifedipine molar ratio of between 10:1 to 1:10.

2 . The composition of claim 1 , wherein the liquid carrier comprises an aqueous solvent.

3 . The composition of claim 2 , wherein the composition further comprises polyethylene glycol 400 as a cosolvent.

4 . The composition of claim 1 , wherein the composition further comprises a citric acid buffer.

5 . The composition of claim 1 , wherein the ketoprofen and nifedipine are included at a ketoprofen to nifedipine molar ratio of between 5:1 to 1:5.

6 . The composition of claim 5 , wherein the ketoprofen and nifedipine are included at a ketoprofen to nifedipine molar ratio of between 4:1 to 1:1.

7 . The composition of claim 6 , wherein the ketoprofen and nifedipine are included at a ketoprofen to nifedipine molar ratio of 3:1 plus or minus 20%.