Compositions and methods for promoting neuronal outgrowth
Neural outgrowth in the central nervous system is achieved by administering chondroitinase AC and/or chondroitinase B to degrade chondroitin sulfate proteoglycans that inhibit or contribute to the inhibition of nervous tissue regeneration.
1. A method of treating a subject having a glial scar due to an injury to the central nervous system comprising administering an effective amount of chondroitinase AC, chondroitinase B, or a mixture thereof to the subject.
2. The method of claim 1 , wherein administering is selected from topical, local and systemic.
3. The method of claim 2 , wherein local administration uses a mode selected from a catheter, a syringe, and direct application to the injury.
4. The method of claim 1 , wherein chondroitinase AC is administered.
5. The method of claim 4 , wherein the chondroitinase AC is selected from the group consisting of chondroitinase AC, chondroitinase AC II and chondroitinase AC III.
6. The method of claim 1 , wherein chondroitinase B is administered.
7. The method of claim 1 , wherein a combination of a chondroitinase AC and chondroitinase B is administered.
8. The method of claim 1 , wherein the chondroitinase AC, chondroitinase B or a mixture thereof is administered as a composition comprising a pharmaceutically acceptable carrier.
9. The method of claim 1 , wherein the effective amount is administered in multiple doses.