Dual polarity spark ion source
View Patent ↗Devices and techniques for ion analysis, including ion mobility separation and mass spectrometry, are provided using a dual polarity spark ion source and having the flexibility required to optimize the detection performance for a broad range of illicit substances with different physical and chemical properties. In various embodiments, the volatility and electro-chemical aspects may be addressed by the system described herein by performing real-time detection of compounds detectable in both positive and negative polarities and/or prioritizing spectra acquisition in a given polarity due to the high volatility and therefore short residence of certain target compounds.
1. An ion analysis device, comprising:
an ion source, the ion source including a spark ion source with a plurality of electrodes, at least a first electrode and a second electrode in the plurality being separated by a gap and configured to permit a spark discharge therebetween; and
a controller that controls a switching frequency of voltage changes to the electrodes of the ion source in order to alternatively push positive ions and negative ions generated by spark discharge from the ion source, wherein the controller includes a computer controlled high voltage fast switching circuit that is able to produce stable voltages during analysis and rapidly switch polarity of the first electrode and the second electrode at any time after completion of a spectrum and wherein the positive ions are pushed in response to the controller providing a first polarity to the first electrode and the second electrode and the negative ions are pushed in response to the controller providing a second polarity to the first electrode and the second electrode that is opposite of the first polarity.
2. The device according to claim 1 , further comprising:
an ion mobility device into which the ions are injected from the ion source.
3. The device according to claim 2 , wherein the ion mobility device includes at least one of: an ion mobility spectrometry (IMS) device, a drift cell or a differential mobility spectrometry (DMS) device.
4. The device according to claim 1 , further comprising:
a vacuum interface into which the ions are received from the ion source; and
an analysis component that receives the ions from the vacuum interface.
5. The device according to claim 1 , wherein polarity switching is provided at a variable frequency which may be selected depending on a duty cycle intended.
6. The device according to claim 1 , wherein the ion source has a point-to-point electrode configuration or a point-to-plane electrode configuration.
7. The device according to claim 1 , wherein the controller controls the switching frequency of the ion source according to real time or non-real time analysis.
8. The device according to claim 1 , wherein the controller controls the switching frequency of the ion source according to an intended duty cycle.
9. The device according to claim 1 , wherein the controller controls the switching frequency to provide a pulsed or a continuous stream of ions from the ion source.
10. A method of controlling ionization processing, comprising:
determining a mode of operation for ion analysis;
determining a switching frequency of voltage changes of electrodes of an ion source, the ion source including a spark ion source with a plurality of electrodes, at least a first electrode and a second electrode in the plurality being separated by a gap and configured to permit a spark discharge therebetween; and
controlling the voltage changes of the electrodes of the ion source during spark ionization according to the determined switching frequency using a controller in order to alternatively push positive ions and negative ions generated by spark discharge from the ion source, wherein the controller includes a computer controlled high voltage fast switching circuit that is able to produce stable voltages during analysis and rapidly switch polarity of the first electrode and the second electrode at any time after completion of a spectrum and wherein the positive ions are pushed in response to the controller providing a first polarity to the first electrode and the second electrode and the negative ions are pushed in response to the controller providing a second polarity to the first electrode and the second electrode that is opposite of the first polarity.
11. The method according to claim 10 , further comprising:
injecting the ions generated by the ion source into an ion mobility device.
12. The method according to claim 11 , wherein the ion mobility device includes at least one of: an ion mobility spectrometry (IMS) device, a drift cell or a differential mobility spectrometry (DMS) device.
13. The method according to claim 10 , further comprising:
using a vacuum interface to inject the ions generated by the ion source into an analysis component.
14. The method according to claim 10 , wherein polarity switching is provided at a variable frequency which may be selected depending on a duty cycle intended.
15. The method according to claim 10 , wherein the ion source has a point-to-point electrode configuration or a point-to-plane electrode configuration.
16. The method according to claim 10 , wherein the controller controls the switching frequency of the ion source according to real time or non-real time analysis.
17. The method according to claim 10 , wherein the controller controls the switching frequency of the ion source according to an intended duty cycle.
18. The method according to claim 10 , wherein the switching frequency is controlled to provide a pulsed or a continuous stream of ions from the ion source.
19. A non-transitory computer-readable medium storing software for controlling ionization processing, the software comprising:
executable code that determines a mode of operation for ion analysis;
executable code that determines a switching frequency of voltage changes of electrodes of an ion source, the ion source including a spark ion source with a plurality of electrodes, at least a first electrode and a second electrode in the plurality being separated by a gap and configured to permit a spark discharge therebetween; and
executable code that controls the voltage changes to the electrodes of the ion source during spark ionization according to the determined switching frequency using a controller in order to alternatively push positive ions and negative ions generated by spark discharge from the ion source, wherein the controller includes a computer controlled high voltage fast switching circuit that is able to produce stable voltages during analysis and rapidly switch polarity of the first electrode and the second electrode at any time after completion of a spectrum and wherein the positive ions are pushed in response to the controller providing a first polarity to the first electrode and the second electrode and the negative ions are pushed in response to the controller providing a second polarity to the first electrode and the second electrode that is opposite of the first polarity.
20. The non-transitory computer-readable medium according to claim 19 , wherein the software further comprises:
executable code that controls injection of the ions generated by the ion source into an ion mobility device.
21. The non-transitory computer-readable medium according to claim 20 , wherein the software further comprises:
executable code that controls selective filtering of the ions after injection into the ion mobility device.
22. The non-transitory computer-readable medium according to claim 19 , further comprising:
executable code that controls injection of the ions generated by the ion source into an analysis component via a vacuum interface.
23. The non-transitory computer-readable medium according to claim 19 , wherein polarity switching is provided at a variable frequency which may be selected depending on a duty cycle intended.
24. The non-transitory computer-readable medium according to claim 19 , wherein the switching frequency of the ion source is controlled according to real time or non-real time analysis.
25. The non-transitory computer-readable medium according to claim 19 , wherein the switching frequency of the ion source is controlled according to an intended duty cycle.
26. The non-transitory computer-readable medium according to claim 19 , wherein the switching frequency is controlled to provide a pulsed or a continuous stream of ions from the ion source.
27. The device according to claim 1 , wherein the controller causes the electrodes to have a first polarity to acquire a plurality of spectra prior to automatically switching the electrodes to an opposite polarity to acquire spectra in the opposite polarity.
28. The method according to claim 10 , further comprising:
the controller causing the electrodes to have a first polarity to acquire a plurality of spectra prior to automatically switching the electrodes to an opposite polarity to acquire spectra in the opposite polarity.
29. The non-transitory computer-readable medium according to claim 19 , wherein the software further comprises:
executable code that causes the electrodes to have a first polarity to acquire a plurality of spectra prior to automatically switching the electrodes to an opposite polarity to acquire spectra in the opposite polarity.