Systems for regulation of blood pressure and heart rate

1. A system comprising:

a) a first electrode adapted to be placed on a vagus nerve at a subdiaphragmatic location and a second electrode adapted to be placed on a sympathetic nerve;

b) an implantable neuroregulator connected to the electrode, wherein the implantable neuroregulator is configured to deliver a first electrical signal to the vagus nerve, wherein the first electrical signal is

i) delivered with a duty cycle of an on time and an off time multiple times in a day;

ii) has a frequency of 200 to 5000 Hz selected to down regulate neural activity on the nerve during an on time,

iii) has an off time selected to provide for at least partial recovery of nerve function, and

iv) has an amplitude of at least 6 mA; and

is configured to deliver a second electrical signal to the sympathetic nerve, wherein the second electrical signal is

i) delivered with a duty cycle of an on time and an off time multiple times in a day;

ii) has a frequency of 200 to 5000 Hz selected to down regulate neural activity on the nerve during an on time,

iii) has an off time selected to provide for at least partial recovery of nerve function;

c) an external coil, wherein the external coil is configured to communicate data and power signals to the neuroregulator and to communicate data to another programming device; and

d) a sensor that is configured to sense blood pressure and to send a signal to the neuroregulator to deliver the electrical signal if the blood pressure becomes pre hypertensive or greater.

2. The system of claim 1 , wherein the neuroregulator is configured to deliver the first electrical signal intermittently for a treatment period of no less than 12 hours and no more than 18 hours.

3. The system of claim 1 , wherein the neuroregulator is configured to deliver the first electrical signal having an on time of 30 seconds to 5 minutes.

4. The system of claim 1 , wherein the neuroregulator is configured to deliver the first electrical signal having an off time of 2 to 20 minutes.

5. The system of claim 1 , wherein the first electrical signal has amplitude from about 6 to 18 mA.

6. The system of claim 1 , wherein the first and second electrical signals are delivered at the same time.

7. The system of claim 1 , wherein the first and second electrical signals are delivered at different times.

8. A method of treating hypertension or congestive heart failure in a subject comprising:

applying a first intermittent electrical treatment signal to a vagus nerve or tissue in proximity to the vagus nerve at a subdiaphragmatic location of the subject having hypertension or congestive heart failure, wherein said first electrical treatment signal is selected to at least partially down-regulate neural activity on the vagus nerve during an on time, have a frequency of about 200 Hz to 25 kHz, and to at least partially restore neural activity on the nerve during an off time; and applying a second intermittent electrical treatment signal to a sympathetic nerve of the subject having hypertension or congestive heart failure, wherein said second electrical treatment signal is selected to at least partially down-regulate neural activity on the sympathetic nerve during an on time, have a frequency of about 200 Hz to 25 kHz, and to at least partially restore neural activity on the nerve during an off time.

9. The method according to claim 8 , wherein the first and second electrical treatment is selected for frequency, pulse width, amplitude, timing and ramp-up/ramp-down characteristics.

10. The method according to claim 8 , wherein the on time of the first electrical treatment signal is selected to down regulate the neural activity of the nerve at least 50%.

11. The method of claim 8 , wherein the first electrical treatment is applied intermittently in a cycle including an on time of application of the signal followed by an off time during which the signal is not applied to the nerve, wherein the on and off times are applied multiple times per day over multiple days.

12. The method of claim 8 , wherein the first electrical treatment has an on time is selected to have duration of no less than 30 seconds or no more than 180 seconds or both.

13. The method according to claim 8 , wherein the first electrical treatment is applied to an anterior vagus trunk, posterior vagus trunk, or both.

14. The method of claim 8 , wherein the first and the second electrical treatment are applied at the same time or different time.

15. The method according to claim 8 , further comprising administering an agent that improves blood pressure control.

16. The method of claim 15 , wherein the agent that improves blood pressure control is selected from the group consisting of a diuretic, ACE inhibitor, calcium channel blocker, beta blocker, alpha blocker and mixtures thereof.