Array of sensors with surface modifications
Surface modifications to sensors in an array give the sensors different functionalities for adsorbing or binding molecules. A first sensor in the array includes a first resonating member having a first surface comprising a receptor material coated over a first underlying material. A second sensor includes a second resonating member having a second surface comprising the receptor material coated over a second underlying material that is different than the first underlying material. The first underlying material, the second underlying material, and the receptor material are selected such that the first resonating member, having a combination of the receptor material and the first underlying material, has a different ability to adsorb or bind a mass of one or more analytes than does the second resonating member having a combination of the receptor material with the second underlying material. Methods for fabricating sensors with surface modifications are also provided.
1. A device comprising:
a) at least first and second resonator sensors, wherein the first sensor includes a first resonating member having a first surface comprising a receptor material coated over a first underlying material, the second sensor includes a second resonating member having a second surface comprising the receptor material coated over a second underlying material that is different than the first underlying material, and the first underlying material, the second underlying material and the receptor material are selected such that the first resonating member, having a combination of the receptor material and the first underlying material, has a different ability to adsorb or bind a mass of one or more analytes than does the second resonating member having a combination of the receptor material with the second underlying material; and
b) at least one detector arranged to detect responses of the sensors when the sensors are exposed to a sample potentially containing one or more of the analytes.
2. The device of claim 1 , wherein the first underlying material comprises gold and the second underlying material comprises silicon, silicon oxide or aluminum oxide.
3. The device of claim 1 , wherein the receptor material comprises 3-Aminopropyltrimethoxysiloxane (AMO).
4. The device of claim 1 , wherein the receptor material comprises a mixture of 3-Aminopropyltrimethoxysiloxane (AMO) and Propyltrimethoxysiloxane (PTMS).
5. The device of claim 1 , further comprising a third resonator sensor that includes a third resonating member having a third surface comprising the receptor material coated over a third underlying material that differs from the first and second underlying materials, wherein the receptor material and the underlying materials are selected such that the first, second and third resonating members have different functionalities for adsorbing or binding molecules of one or more of the analytes.
6. The device of claim 1 , wherein the underlying materials comprise different metals.
7. The device of claim 1 , wherein the sensor responses comprise changes in resonance frequencies.
8. The device of claim 1 , further comprising at least one processor in communication with the detector for receiving data representative of the sensor responses, wherein the at least one processor is programmed to determine the presence or amount of the analytes according to the data.
9. The device of claim 1 , wherein each of the resonator sensors comprises a capacitive micromachined ultrasound transducer (cMUT).