Systems and methods for modeling changes in patient-specific blood vessel geometry and boundary conditions
View Patent ↗Systems and methods are disclosed for modeling changes in patient-specific blood vessel geometry and boundary conditions resulting from changes in blood flow or pressure. One method includes determining, using a processor, a first anatomic model of one or more blood vessels of a patient; determining a biomechanical model of the one or more blood vessels based on at least the first anatomic model; determining one or more parameters associated with a physiological state of the patient; and creating a second anatomic model based on the biomechanical model and the one or more parameters associated with the physiological state.
1. A computer-implemented method of anatomical modeling, the method comprising:
receiving image data of one or more blood vessels of a patient's anatomy obtained while the patient's body is at a first physiological state;
determining, using a processor, a patient-specific anatomic model of the one or more blood vessels from the image data obtained while the patient's body is at the first physiological state;
determining, using a processor, a patient-specific biomechanical model of the one or more blood vessels from the image data obtained while the patient's body is at the first physiological state;
determining a second physiological state of the patient's body different from the first physiological state, wherein the second physiological state includes a hyperemic state, an exercise state, or a medicated state;
performing one or more updates to the biomechanical model using parameters associated with the second physiologic state of the patient's body;
updating the anatomic model to incorporate a geometric change associated with the parameter associated with the second physiologic state of the patient's body and at least one of the updates to the biomechanical model;
determining a treatment for modifying the patient's anatomy; and
modifying the updated anatomic model to incorporate a geometric change associated with the treatment for modifying the patient's anatomy.
2. The method of claim 1 , wherein the treatment for modifying the patient's body includes angioplasty, stenting, or bypass surgery.
3. The method of claim 2 , wherein the geometric change associated with the treatment for modifying the patient's anatomy includes geometry associated with the angioplasty, the stenting, or the bypass surgery.
4. The method of claim 1 , wherein updating the anatomic model further includes:
determining a vessel cross-sectional area using pressure associated with the second physiological state.
5. The method of claim 1 , further comprising:
receiving patient information; and
predicting the cross-sectional area using the patient information.
6. The method of claim 5 , wherein the patient information includes a local change to a cross-sectional area of a vessel in response to a change in pressure or surrounding geometry.
7. The method of claim 1 , further comprising:
performing a simulation using the updated anatomic model or the modified updated model; and
providing a treatment recommendation using the simulation.
8. The method of claim 1 , further comprising: displaying the updated anatomic model or the modified updated anatomic model.
9. The method of claim 1 , wherein updating the anatomic model includes determining a second patient-specific anatomic model.
10. A system for anatomical modeling, the system comprising:
a data storage device storing instructions for anatomical modeling; and
a processor configured to execute the instructions to perform a method including:
receiving image data of one or more blood vessels of a patient's anatomy obtained while the patient's body is at a first physiological state;
determining, using a processor, a patient-specific anatomic model of one or more blood vessels from the image data obtained while the patient's body is at the first physiological state;
determining, using a processor, a patient-specific biomechanical model of the one or more blood vessels from the image data obtained while the patient's body is at the first physiological state;
determining a second physiological state of the patient's body different from the first physiological state, wherein the second physiological state includes a hyperemic state, an exercise state, or a medicated state;
performing one or more updates to the biomechanical model using parameters associated with the second physiologic state of the patient's body;
updating the anatomic model to incorporate a geometric change associated with the parameter associated with the second physiologic state of the patient's body and at least one of the updates to the biomechanical model;
determining a treatment for modifying the patient's anatomy; and
modifying the updated anatomic model to incorporate a geometric change associated with the treatment for modifying the patient's anatomy.
11. The system of claim 10 , wherein the treatment for modifying the patient's body includes medical therapy, including angioplasty, stenting, or bypass surgery.
12. The system of claim 11 , wherein the geometric change associated with the treatment for modifying the patient's anatomy includes geometry associated with the angioplasty, the stenting, or the bypass surgery.
13. The system of claim 10 , wherein updating the anatomic model further includes:
determining a vessel cross-sectional area using pressure associated with the second physiological state.
14. The system of claim 13 , wherein the system is further configured for:
receiving patient information; and
predicting the cross-sectional area using the patient information.
15. The system of claim 14 , wherein the patient information includes a local change to a cross-sectional area of a vessel in response to a change in pressure or surrounding geometry.
16. The system of claim 10 , wherein the system is further configured for:
performing a simulation based on the updated anatomic model or the modified updated model; and
providing a treatment recommendation using the simulation.
17. The system of claim 10 , wherein the system is further configured for:
displaying the updated anatomic model or the modified updated model.
18. The system of claim 10 , wherein updating the anatomic model includes determining a second patient-specific anatomic model.
19. A non-transitory computer readable medium for use on a computer system containing computer-executable programming instructions for performing a method of anatomical modeling, the method comprising:
receiving image data of one or more blood vessels of a patient's anatomy obtained while the patient's body is at a first physiological state;
determining, using a processor, a patient-specific anatomic model of one or more blood vessels from the image data obtained while the patient's body is at the first physiological state;
determining, using a processor, a patient-specific biomechanical model of the one or more blood vessels from the image data obtained while the patient's body is at the first physiological state;
determining a second physiological state of the patient's body different from the first physiological state, wherein the second physiological state includes a hyperemic state, an exercise state, or a medicated state;
performing one or more updates to the biomechanical model using parameters associated with the second physiologic state of the patient's body;
updating the anatomic model to incorporate a geometric change associated with the parameter associated with the second physiologic state of the patient's body and at least one of the updates to the biomechanical model;
determining a treatment for modifying the patient's anatomy; and
modifying the updated anatomic model to incorporate a geometric change associated with the treatment for modifying the patient's anatomy.
20. The non-transitory computer readable medium of claim 19 , wherein the treatment for modifying the patient's body includes angioplasty, stenting, or bypass surgery.
21. The non-transitory computer readable medium of claim 20 , wherein the geometric change associated with the treatment for modifying the patient's anatomy includes geometry associated with the angioplasty, the stenting, or the bypass surgery.
22. The non-transitory computer readable medium of claim 19 , wherein updating the anatomic model further comprises:
determining a vessel cross-sectional area using pressure associated with the second physiological state.
23. The non-transitory computer readable medium of claim 19 , wherein updating anatomic model includes determining a second patient-specific anatomic model.
24. A computer-implemented method of anatomical modeling, the method comprising:
receiving image data of one or more blood vessels of a patient's anatomy obtained while the patient's body is at a first physiological state, wherein the first physiological state includes a hyperemic state, an exercise state, or a medicated state;
determining, using a processor, a patient-specific anatomic model of one or more blood vessels from the image data obtained while the patient's body is at the first physiological state;
determining, using a processor, a patient-specific biomechanical model of the one or more blood vessels from the image data obtained while the patient's body is at the first physiological state;
determining a second physiological state of the patient's body different from the first physiological state;
performing one or more updates to the biomechanical model using parameters associated with the second physiologic state of the patient's body;
updating the anatomic model to incorporate a geometric change associated with the parameter associated with the second physiologic state of the patient's body and at least one of the updates to the biomechanical model;
determining a treatment for modifying the patient's anatomy; and
modifying the updated anatomic model to incorporate a geometric change associated with the treatment for modifying the patient's anatomy.