IP Library › Granted Patent US 9,226,974
Granted Patent B2
US 9,226,974 · App. 14/324,480 · Granted Jan 5, 2016

Antiproliferative compounds, conjugates thereof, methods therefor, and uses thereof

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Quick Facts
Patent No.
US 9,226,974
App. No.
14/324,480
Granted
Jan 5, 2016
Kind
B2
Abstract

Antiproliferative compounds having a structure represented by formula (II), where n, R 1 , R 2 , R 3 , R 4 , and R 5 are as defined herein, can be used to treat tumors, optionally when conjugated to a ligand such as an antibody:

Claims (9)

1. A conjugate having a structure according to the formula

where Ab represents an antibody.

2. A conjugate according to claim 1 , wherein Ab is a monoclonal antibody.

3. A conjugate according to claim 1 , wherein Ab is a human monoclonal antibody.

4. A conjugate according to claim 1 , wherein Ab is an anti-PSMA (prostate specific membrane antigen) antibody, an anti-CD70 antibody, or an anti-mesothelin antibody.

5. A conjugate according to claim 1 , wherein Ab is an anti-CD70 antibody.

6. A conjugate according to claim 5 , wherein the anti-CD70 antibody is antibody 2H5.

7. A conjugate according to claim 1 , wherein Ab is an anti-mesothelin antibody.

8. A conjugate according to claim 7 , wherein the anti-mesothelin antibody is antibody 6A4.

Assignments (1)
MERGER Recorded Mar 19, 2015
From: MEDAREX, L.L.C.
To: E. R. SQUIBB & SONS, L.L.C.
Reel/Frame 035226/0690 →