Methods of preparing non-alcohol bioactive essential oil mouth rinses
View Patent ↗The invention relates generally to liquids such as mouth rinses for the prevention and elimination of bad breath as well as for the reduction of oral microorganisms responsible for the development of dental plaque and tooth decay. In particular, the present invention relates to a method of preparing non-alcohol or reduced alcohol mouth rinses effective at preventing the above-mentioned problems.
1. A method for preparing a liquid composition comprising the steps of:
a) preparing a first premix composition comprising propylene glycol, an antimicrobial essential oil, and optionally, a flavor;
b) preparing a second premix composition comprising propylene glycol, and an organic acid selected from the group consisting of ascorbic acid, sorbic acid, citric acid, glycolic acid, lactic acid and acetic acid, benzoic acid, salicylic acid, phthalic acid, phenolsulphonic acid, succinic acid and mixtures thereof;
c) preparing a third premix composition comprising at least one surfactant selected from the group consisting of alkyl sulfates, Poloxamers, and combinations thereof, and an aqueous phase comprising water; and
d) adding the first premix to the third premix;
e) mixing the composition of step d) until uniform and homogeneous;
f) adding the second premix to the composition of step e) and mixing until uniform and homogeneous; and
g) adding a sugar alcohol solvent to the composition of step f) and mixing the composition until uniform and homogeneous;
wherein the liquid composition resulting from step g) comprises from about 0.001 to about 0.35 w/v % of antimicrobial essential oils, from about 5 to about 15 w/v % of propylene glycol, from about 0.001 to about 1% w/v of flavor, from about 0.001 to about 1.0 w/v % of organic acid, about 2 w/v % or less of total surfactant, and from about 5 to about 15 w/v % of sugar alcohol solvent.
2. The method of claim 1 wherein the liquid composition is essentially free of alcohol.
3. The method of claim 1 , wherein the antimicrobial essential oil is selected from the group consisting of menthol, eucalyptol, methyl salicylate, thymol and mixtures thereof.
4. The method of claim 3 , wherein the antimicrobial essential oil is a mixture of menthol, eucalyptol, methyl salicylate and thymol.
5. The method of claim 1 , wherein the organic acid comprises benzoic acid.
6. The method of claim 1 , wherein surfactant is selected from sodium lauryl sulfate, Poloxmer 407, or a combination thereof.
7. The method of claim 1 , wherein the sugar alcohol solvent comprises sorbitol.
8. The method of claim 1 , wherein the liquid composition resulting from step g) has a turbidity of less than about 12 Nephelometric Turbidity Units.
9. The method of claim 8 , wherein the liquid composition resulting from step g) has a turbidity of less than about 10 Nephelometric Turbidity Units.
10. The method of claim 9 , wherein the liquid composition resulting from step g) has a turbidity of less than about 8 Nephelometric Turbidity Units.