Inhibitors of NEDD8-activating enzyme
Disclosed are chemical entities which are inhibitors of Nedd8-activating enzyme (NAE), namely, the compound {(1S,2S,4R)-4-[(6-{[(1R,2S)-5-chloro-2-methoxy-2,3-dihydro-1H-inden-1-yl]amino}pyrimidin-4-yl)oxy]-2-hydroxycyclopentyl}methyl sulfamate and pharmaceutically acceptable salts thereof; solid state forms thereof; and prodrugs thereof. Also disclosed are methods of using the chemical entities to treat disorders such as cancer.
1. A chemical entity comprising a hydrochloride salt of the compound {(1S,2S,4R)-4-[(6-{[(1R,2S)-5-chloro-2-methoxy-2,3-dihydro-1H-inden-1-yl]amino}pyrimidin-4-yl)oxy]-2-hydroxycyclopentyl}methyl sulfamate or a pharmaceutically acceptable solvate thereof, wherein said chemical entity is substantially crystalline Form II.
2. A prodrug of a chemical entity, wherein:
the chemical entity is the compound {(1S,2S,4R)-4-[(6-{[(1R,2S)-5-chloro-2-methoxy-2,3-dihydro-1H-inden-1-yl]amino}pyrimidin-4-yl)oxy]-2-hydroxycyclopentyl}methyl sulfamate or a pharmaceutically acceptable salt thereof; and
the prodrug is a carbamate or amide of an NH group of the chemical entity, or an ether or ester of an OH group of the chemical entity.
3. A composition comprising the chemical entity of claim 1 , and a pharmaceutically acceptable carrier.
4. The composition of claim 3 suitable for oral administration.
5. The chemical entity of claim 1 , wherein at least 70% by weight is crystalline Form II.
6. The chemical entity of claim 1 , wherein at least 80% by weight is crystalline Form II.
7. The chemical entity of claim 1 , wherein at least 90% by weight is crystalline Form II.
8. The chemical entity of claim 1 , wherein at least 95% by weight is crystalline Form II.
9. The chemical entity of claim 1 , wherein Form II is characterized by an x-ray powder diffraction (XRPD) pattern having peaks at 2θ angles of 8.7°, 15.2°, 15.7°, 19.6°, and 24.2°, wherein each 2θ angle value is ±0.2°.
10. The chemical entity of claim 9 , wherein Form II is characterized by an XRPD pattern having peaks at 2θ angles of 4.3°, 8.7°, 15.2°, 15.7°, 19.6°, 20.0°, 20.8°, 22.5°, 23.1°, and 24.2°, wherein each 2θ angle value is ±0.2°.
11. The chemical entity of claim 9 , wherein Form II is characterized by an XRPD pattern having peaks at 2θ angles of 4.3°, 8.7°, 12.4°, 14.5°, 15.2°, 15.7°, 17.3°, 18.2°, 18.5°, 19.6°, 20.0°, 20.8°, 22.0°, 22.5°, 23.1°, 24.2°, 24.7°, 25.7°, 28.2° and 29.4°, wherein each 2θ angle value is ±0.2°.
12. The chemical entity of claim 1 , wherein Form II is characterized by an x-ray powder diffraction (XRPD) pattern having a reference peak with a 2θ angle of 8.7±0.3°, and having peaks at 2θ angles of −4.4°, 6.5°, 7.0°, 10.9°, 11.3°, 12.1°, 13.8°, 14.4°, and 15.5° relative to the reference peak.
13. The chemical entity of claim 1 , wherein Form II is characterized by an x-ray powder diffraction (XRPD) pattern having a reference peak with a 2θ angle of 8.7±0.3°, and having peaks at 2θ angles of −4.4°, 3.7°, 5.8°, 6.5°, 7.0°, 8.6°, 9.5°, 9.8°, 10.9°, 11.3°, 13.3°, 13.8°, 14.4°, 15.5°, 16.0°, 17.0°, 19.5° and 20.7° relative to the reference peak.
14. The chemical entity of claim 1 , wherein Form II is characterized by an x-ray powder diffraction (XRPD) pattern substantially as shown in FIG. 10 .
15. A composition comprising the prodrug of claim 2 and a pharmaceutically acceptable carrier.