Pre-loaded syringes and methods related thereto
View Patent ↗Pre-loaded syringes for delivering an embolic agent are disclosed herein. Methods related to syringes pre-loaded with an embolic agent are also disclosed.
1. A pre-loaded syringe comprising:
a silicon-free polymeric barrel at least partially loaded with a dry embolic agent, wherein the barrel comprises a silicon-free fluorinated lubricant cross-linked with an interior surface of the barrel, wherein the silicon-free fluorinated lubricant comprises a perfluoropolyether; and
a plunger in communication with the interior surface of the barrel, wherein the plunger comprises a silicon-free plunger tip,
wherein less than 10% of the dry embolic agent agglomerates after being stored in the barrel for a period of at least six months.
2. The pre-loaded syringe of claim 1 , wherein the embolic agent comprises a microsphere.
3. The pre-loaded syringe of claim 1 , wherein the dry embolic agent is drug-loadable and exhibits a first loading capacity prior to being loaded in the barrel and a second loading capacity after being stored in the barrel for a period of at least six months, wherein the second loading capacity is within 15% of the first loading capacity.
4. The pre-loaded syringe of claim 1 , wherein the syringe comprises sterilization compatible materials.
5. The pre-loaded syringe of claim 1 , wherein the syringe comprises irradiation compatible materials.
6. A kit comprising a pre-loaded syringe comprising:
a silicon-free polymeric barrel comprising a silicon-free perfluoropolyether lubricant cross-linked with en an interior surface of the barrel and at least partially loaded with a dry embolic agent, wherein the dry embolic agent is drug-loadable and exhibits a first loading capacity prior to being loaded in the barrel and a second loading capacity after being stored in the barrel for a period of at least six months, wherein the second loading capacity is within 15% of the first loading capacity; and
a plunger in communication with the interior surface of the barrel.
7. The kit of claim 6 , wherein the embolic agent comprises a polyvinyl alcohol embolic agent.
8. The kit of claim 6 , wherein the plunger comprises a silicon-free plunger tip.
9. The kit of claim 8 wherein the polymeric barrel comprises a cyclo-olefin copolymer or a cyclo-olefin polymer.
10. The kit of claim 6 , wherein less than 10% of the dry embolic agent agglomerates after being stored in the syringe for a period of at least six months.
11. A method of embolizing a blood vessel, the method comprising:
removing a syringe pre-loaded with a dry embolic agent from its packaging, wherein the syringe comprises a silicon-free polymeric barrel comprising a silicon-free perfluoropolyether lubricant cross-linked with an interior surface of the barrel, wherein the dry embolic agent comprises a polyvinyl alcohol embolic agent, wherein less than 10% of the dry embolic agent agglomerates after being stored in the syringe for a period of at least six months;
filling the barrel of the syringe with a volume of liquid to suspend the pre-loaded embolic agent; and
injecting the suspended embolic agent into the blood vessel to embolize the blood vessel.
12. The method of claim 11 , wherein the dry embolic agent is drug-loadable and exhibits a first loading capacity prior to being loaded in the barrel and a second loading capacity after being stored in the barrel for a period of at least six months, wherein the second loading capacity is within 15% of the first loading capacity.