Pharmaceutical compositions comprising renewably-based biodegradable 1,3-propanediol
Biodegradable pharmaceutical compositions comprising 1,3-propanediol and its esters are provided. The 1,3-propanediol and its esters in the pharmaceutical composition are biologically derived, and as such, the pharmaceutical compositions exhibit a low anthropogenic CO 2 emission profile.
1. A pharmaceutical composition comprising an ester of 1,3-propanediol, wherein the composition is biodegradable, wherein the ester is a monomer and comprises at least 3% biobased carbon, and wherein said composition has a lower anthropogenic CO2 emission profile as compared to a biodegradable composition comprising an ester of 1,3-propanediol with a bio-based carbon content of 0%.
2. The composition of claim 1 , wherein the pharmaceutical composition further comprises a botanical, vegetal, protein, peptide, marine extract, algae extract, milk extract, fragrance concentrate or oil.
3. The composition of claim 1 , wherein the pharmaceutical composition comprises a is pharmaceutical transdermal composition.
4. The composition of claim 1 , wherein the ester has 50% biobased carbon.
5. The composition of claim 1 , wherein the ester has 100% biobased carbon.
6. The composition of claim 1 , wherein the ester has the formula R1-C(═O)—O—CH2-CH2-CH2-OH, wherein R1 is a linear or branched carbon chain of a length between about 1 and about 40 carbons.
7. The composition of claim 1 , wherein the ester has the formula R1-C(═O)—O—CH2-CH2-CH2-O—C(═O)—R2, wherein R1 and R2 are linear or branched carbon chains of a length between about 1 and about 40 carbons.
8. The composition of claim 1 , wherein the ester is selected from the group consisting of:
i. propanediol distearate, monostearate and a mixture thereof;
ii. propandiol dilaurate, monolaurate and a mixture thereof;
iii. propanediol dioleate, monooleate and a mixture thereof;
iv. propanediol divalerate, monovalerate and a mixture thereof;
v. propanediol dicaprylate, monocaprylate and a mixture thereof;
vi. propanediol dimyristate, monomyristate and a mixture thereof;
vii. propanediol dipalmitate, monopalmitate and a mixture thereof;
viii. propanediol dibehenate, monobehenate and a mixture thereof;
ix. propanediol adipate;
x. propanediol maleate;
xi. propanediol dibenzoate;
xii. propanediol diacetate; and
xiii. mixtures thereof.
9. The composition of claim 1 , further comprising 1,3-propanediol.
10. The composition of claim 9 , wherein the 1,3-propanediol has 50% biobased carbon.
11. The composition of claim 9 , wherein the 1,3-propanediol has 100% biobased carbon.
12. A pharmaceutical composition comprising 1,3-propanediol, wherein the 1,3-propanediol is biologically derived, wherein the composition is biodegradable and has a lower anthropogenic CO2 emission profile as compared to a biodegradable composition comprising 1,3-propanediol with a bio-based carbon content of 0%, and wherein the 1,3-propanediol is a monomer, and comprises at least 3% biobased carbon.
13. The composition of claim 12 , wherein the pharmaceutical composition further comprises a botanical, vegetal, protein, peptide, marine extract, algae extract, milk extract, fragrance concentrate or oil.
14. The composition of claim 12 , wherein the pharmaceutical composition comprises a pharmaceutical transdermal composition.
15. The composition of claim 12 , wherein the 1,3-propanediol has 50% biobased carbon.
16. The composition of claim 12 , wherein the 1,3-propanediol has 100% biobased carbon.
17. A pharmaceutical composition comprising renewably-based, biodegradable 1,3-propanediol or an ester thereof, wherein upon biodegradation the renewably-based, biodegradable 1,3-propanediol or ester thereof in said composition contributes no net CO2 emissions to the atmosphere.
18. A method for providing an extract or dilution of an extract for pharmaceutic formulations comprising:
a) employing biologically derived 1,3-propanediol or its ester conjugate for extraction or dilution of a botanical, vegetal, protein, peptide, marine extract, algae extract, milk extract, fragrance concentrate or oil; and
b) incorporating said botanical, vegetal, protein, peptide, marine extract, algae extract, milk extract, fragrance concentrate or oil into a pharmaceutic formulation.