IP Library › Granted Patent US 9,370,487
Granted Patent B2
US 9,370,487 · App. 14/334,952 · Granted Jun 21, 2016

High oil-content emollient aerosol foam compositions

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Quick Facts
Patent No.
US 9,370,487
App. No.
14/334,952
Granted
Jun 21, 2016
Kind
B2
Abstract

Described herein are high oil-content emulsions and compositions for the treatment of inflammatory skin disorders. The emulsions may be formulated as aerosol compositions. The aerosol propellant may be a hydrofluoroalkane propellant. The emulsions or compositions may comprise active agents, such as corticosteroids. Also described are methods of treating inflammatory skin disorders, comprising the step of applying to an affected area of a subject in need thereof a therapeutically-effective amount of an inventive emulsion or aerosol composition.

Claims (181)

1. A composition, comprising:

an emulsion, wherein the emulsion comprises

an oil phase, wherein the oil phase comprises an emulsifier or surfactant, a first moisturizer or first emollient, and a first antioxidant or first preservative;

an aqueous phase, wherein the aqueous phase comprises water, a second moisturizer or second emollient, and a second antioxidant or second preservative; and

an active agent;

a propellant; and

a purge gas,

wherein the emulsion has a viscosity of 100,000 to 350,000 cp, and

wherein the emulsion, upon expulsion from an aerosol container, forms a foam having a density from 0.05 to 0.5 g/cm 3 .

2. The composition of claim 1 , wherein the emulsifier or surfactant is selected from the group consisting of Ceteth-20, cetostearyl alcohol, and combinations/mixtures thereof.

3. The composition of claim 1 , wherein the first moisturizer or first emollient is selected from the group consisting of mineral oil, petrolatum, dimethicone, safflower oil, oleic acid, stearic acid, oleyl alcohol, and combinations/mixtures thereof.

4. The composition of claim 1 , wherein the first antioxidant or first preservative is selected from the group consisting of imidazolidinyl urea, diazolidinyl urea, phenoxyethanol, sodium methyl paraben, methylparaben, ethylparaben, propylparaben, potassium sorbate, sodium benzoate, sorbic acid, benzoic acid, formaldehyde, citric acid, sodium citrate, chlorine dioxide, benzalkonium chloride, benzethonium chloride, cetrimide, dequalinium chloride, cetylpyridinium chloride, phenylmercuric nitrate, phenylmercuric acetate, thimerosal, piroctone olamine, Vitis vinifera seed oil, chlorobutanol, dichlorobenzyl alcohol, phenylethyl alcohol, benzyl alcohol, ascorbic acid, sodium bisulfite, butylated hydroxytoluene, butylated hydroxyanisole, α-tocopherol, tocopheryl acetate, sodium ascorbate/ascorbic acid, ascorbyl palmitate, propyl gallate, disodium EDTA, citric acid, and sodium citrate, and combinations/mixtures thereof.

5. The composition of claim 1 , wherein the second moisturizer or second emollient is selected from the group consisting of glycerol, urea, and combinations/mixtures thereof.

6. The composition of claim 1 , wherein the second antioxidant or second preservative is selected from the group consisting of methylparaben, propylparaben, citric acid, sodium citrate, and combinations/mixtures thereof.

7. The composition of claim 1 , wherein the active agent is selected from the group consisting of corticosteroids, vitamin D analogues, retinoids, immunomodulators, antifungals, and combinations/mixtures thereof.

8. The composition of claim 1 , wherein the active agent is selected from the group consisting of hydrocortisone butyrate, betamethasone dipropionate, and combinations/mixtures thereof.

9. The composition of claim 1 , wherein the active agent is selected from the group consisting of vitamin A, vitamin D, vitamin E, vitamin K, vitamin D analogue calcipotriene, vitamin D analogue calcipotriol, and combinations/mixtures thereof.

10. The composition of claim 1 , wherein the active agent is a retinoid.

11. The composition of claim 1 , wherein

the emulsion comprises:

Ceteth-20, from about 1% to about 5% by weight of the emulsion;

cetostearyl alcohol, from about 3% to about 9% by weight of the emulsion;

mineral oil, from about 1% to about 18% by weight of the emulsion;

petrolatum, from about 3% to about 11% by weight of the emulsion;

dimethicone, from about 0.5% to about 2.0% by weight of the emulsion;

safflower oil, from about 0% to about 11% by weight of the emulsion;

oleic acid, from about 0% to about 11% by weight of the emulsion;

stearic acid, from about 0% to about 1% by weight of the emulsion;

oleyl alcohol, from about 0% to about 15% by weight of the emulsion;

butylated hydroxytoluene, from about 0.01% to about 0.05% by weight of the emulsion;

water, from about 27% to about 82% by weight of the emulsion;

glycerin, from about 2.5% to about 7.5% by weight of the emulsion;

urea, from about 0.3% to about 0.9% by weight of the emulsion;

citric acid, from about 0.2% to about 0.6% by weight of the emulsion;

sodium citrate, from about 0.1% to about 0.5% by weight of the emulsion;

methylparaben, from about 0.1% to about 0.5% by weight of the emulsion;

propylparaben, from about 0.05% to about 0.20% by weight of the emulsion; and

an active agent, from about 0.002% to about 0.20% by weight of the emulsion.

12. The composition of claim 1 ,

wherein the emulsion comprises:

Ceteth-20, in about 3.00% by weight of the emulsion;

cetostearyl alcohol, in about 6.00% by weight of the emulsion;

mineral oil, in about 12.38% by weight of the emulsion;

petrolatum, in about 7.50% by weight of the emulsion;

dimethicone, in about 1.00% by weight of the emulsion;

safflower oil, in about 6.75% by weight of the emulsion;

butylated hydroxytoluene, in about 0.03% by weight of the emulsion;

water, in about 54.46% by weight of the emulsion;

glycerin, in about 5.00% by weight of the emulsion;

urea, in about 0.64% by weight of the emulsion;

citric acid, in about 0.42% by weight of the emulsion;

sodium citrate, in about 0.32% by weight of the emulsion;

methylparaben, in about 0.30% by weight of the emulsion;

propylparaben, in about 0.10% by weight of the emulsion; and

hydrocortisone butyrate, in about 0.10% by weight of the emulsion.

13. The composition of claim 1 , comprising wherein

the emulsion comprises

Ceteth-20, in about 3.00% by weight of the emulsion;

cetostearyl alcohol, in about 6.00% by weight of the emulsion;

mineral oil, in about 12.38% by weight of the emulsion;

petrolatum, in about 7.50% by weight of the emulsion;

dimethicone, in about 1.00% by weight of the emulsion;

safflower oil, in about 6.75% by weight of the emulsion;

oleic acid, in about 0.50% by weight of the emulsion;

stearic acid, in about 0.50% by weight of the emulsion;

butylated hydroxytoluene, in about 0.03% by weight of the emulsion;

water, in about 55.46% by weight of the emulsion;

glycerin, in about 5.00% by weight of the emulsion;

urea, in about 0.64% by weight of the emulsion;

citric acid, in about 0.42% by weight of the emulsion;

sodium citrate, in about 0.32% by weight of the emulsion;

methylparaben, in about 0.30% by weight of the emulsion;

propylparaben, in about 0.10% by weight of the emulsion; and

hydrocortisone butyrate, in about 0.10% by weight of the emulsion.

14. The composition of claim 1 , wherein

the emulsion comprises:

Ceteth-20, in about 3.00% by weight of the emulsion;

cetostearyl alcohol, in about 6.00% by weight of the emulsion;

mineral oil, in about 12.38% by weight of the emulsion;

petrolatum, in about 7.50% by weight of the emulsion;

dimethicone, in about 1.00% by weight of the emulsion;

safflower oil, in about 6.75% by weight of the emulsion;

butylated hydroxytoluene, in about 0.03% by weight of the emulsion;

water, in about 56.51% by weight of the emulsion;

glycerin, in about 5.00% by weight of the emulsion;

urea, in about 0.64% by weight of the emulsion;

citric acid, in about 0.42% by weight of the emulsion;

sodium citrate, in about 0.32% by weight of the emulsion;

methylparaben, in about 0.30% by weight of the emulsion;

propylparaben, in about 0.10% by weight of the emulsion; and

betamethasone dipropionate, in about 0.05% by weight of the emulsion.

15. The composition of claim 1 , wherein

the emulsion comprises:

Ceteth-20, in about 3.00% by weight of the emulsion;

cetostearyl alcohol, in about 6.00% by weight of the emulsion;

mineral oil, in about 2.38% by weight of the emulsion;

petrolatum, in about 6.85% by weight of the emulsion;

dimethicone, in about 1.00% by weight of the emulsion;

oleic acid, in about 7.40% by weight of the emulsion;

oleyl alcohol, in about 10.00% by weight of the emulsion;

butylated hydroxytoluene, in about 0.03% by weight of the emulsion;

water, in about 56.51% by weight of the emulsion;

glycerin, in about 5.00% by weight of the emulsion;

urea, in about 0.64% by weight of the emulsion;

citric acid, in about 0.42% by weight of the emulsion;

sodium citrate, in about 0.32% by weight of the emulsion;

methylparaben, in about 0.30% by weight of the emulsion;

propylparaben, in about 0.10% by weight of the emulsion; and

betamethasone dipropionate, in about 0.05% by weight of the emulsion.

16. The composition of claim 1 , wherein

the emulsion comprises:

Ceteth-20, in about 3.00% by weight of the emulsion;

cetostearyl alcohol, in about 6.00% by weight of the emulsion;

mineral oil, in about 12.38% by weight of the emulsion;

petrolatum, in about 7.50% by weight of the emulsion;

dimethicone, in about 1.00% by weight of the emulsion;

safflower oil, in about 6.75% by weight of the emulsion;

butylated hydroxytoluene, in about 0.03% by weight of the emulsion;

water, in about 56.54% by weight of the emulsion;

glycerin, in about 5.00% by weight of the emulsion;

urea, in about 0.64% by weight of the emulsion;

citric acid, in about 0.42% by weight of the emulsion;

sodium citrate, in about 0.32% by weight of the emulsion;

methylparaben, in about 0.30% by weight of the emulsion;

propylparaben, in about 0.10% by weight of the emulsion; and

tretinoin, in about 0.02% by weight of the emulsion.

17. The composition of claim 1 , wherein

the emulsion comprises:

Ceteth-20, in about 3.00% by weight of the emulsion;

cetostearyl alcohol, in about 6.00% by weight of the emulsion;

mineral oil, in about 12.38% by weight of the emulsion;

petrolatum, in about 7.50% by weight of the emulsion;

dimethicone, in about 1.00% by weight of the emulsion;

safflower oil, in about 6.75% by weight of the emulsion;

butylated hydroxytoluene, in about 0.03% by weight of the emulsion;

water, in about 56.555% by weight of the emulsion;

glycerin, in about 5.00% by weight of the emulsion;

urea, in about 0.64% by weight of the emulsion;

citric acid, in about 0.42% by weight of the emulsion;

sodium citrate, in about 0.32% by weight of the emulsion;

methylparaben, in about 0.30% by weight of the emulsion;

propylparaben, in about 0.10% by weight of the emulsion; and

calcipotriene, in about 0.005% by weight of the emulsion.

18. The composition of claim 1 , wherein

the emulsion comprises:

Ceteth-20, in about 3.00% by weight of the emulsion;

cetostearyl alcohol, in about 6.00% by weight of the emulsion;

mineral oil, in about 12.38% by weight of the emulsion;

petrolatum, in about 7.50% by weight of the emulsion;

dimethicone, in about 1.00% by weight of the emulsion;

safflower oil, in about 6.75% by weight of the emulsion;

butylated hydroxytoluene, in about 0.03% by weight of the emulsion;

water, in about 56.505% by weight of the emulsion;

glycerin, in about 5.00% by weight of the emulsion;

urea, in about 0.64% by weight of the emulsion;

citric acid, in about 0.42% by weight of the emulsion;

sodium citrate, in about 0.32% by weight of the emulsion;

methylparaben, in about 0.30% by weight of the emulsion;

propylparaben, in about 0.10% by weight of the emulsion;

betamethasone dipropionate, in about 0.05% by weight of the emulsion; and

calcipotriene, in about 0.005% by weight of the emulsion.

19. The composition of claim 1 , wherein

the emulsion comprises:

Ceteth-20, in about 3.00% by weight of the emulsion;

cetostearyl alcohol, in about 6.00% by weight of the emulsion;

mineral oil, in about 12.38% by weight of the emulsion;

petrolatum, in about 7.50% by weight of the emulsion;

dimethicone, in about 1.00% by weight of the emulsion;

safflower oil, in about 6.75% by weight of the emulsion;

butylated hydroxytoluene, in about 0.03% by weight of the emulsion;

water, in about 56.49% by weight of the emulsion;

glycerin, in about 5.00% by weight of the emulsion;

urea, in about 0.64% by weight of the emulsion;

citric acid, in about 0.42% by weight of the emulsion;

sodium citrate, in about 0.32% by weight of the emulsion;

methylparaben, in about 0.30% by weight of the emulsion;

propylparaben, in about 0.10% by weight of the emulsion;

betamethasone dipropionate, in about 0.05% by weight of the emulsion; and

tretinoin, in about 0.02% by weight of the emulsion.

20. The composition of claim 1 , wherein the emulsion includes cetostearyl alcohol at 3 to 9% by weight of the emulsion.

21. The composition of claim 20 , wherein the emulsion includes ceteth-20 at 1 to 5% by weight of the emulsion.

Assignments (18)
RELEASE OF SECURITY INTEREST Recorded Nov 20, 2025
From: THE BANK OF NEW YORK MELLON, AS NOTES COLLATERAL AGENT
To: ATON PHARMA, INC.; BAUSCH & LOMB INCORPORATED; BAUSCH & LOMB PHARMA HOLDINGS CORP.; COMMONWEALTH LABORATORIES, LLC; DOW PHARMACEUTICAL SCIENCES, INC.; ECR PHARMACEUTICALS CO., INC.; LABORATOIRE CHAUVIN S.A.S.; MEDICIS PHARMACEUTICAL CORPORATION; ONPHARMA INC.; ORAPHARMA, INC.; PRECISION DERMATOLOGY, INC.; SALIX PHARMACEUTICALS, LTD.; SALIX PHARMACEUTICALS, INC.; SANTARUS, INC.; SOLTA MEDICAL, INC.; SYNERGETICS USA, INC.; TECHNOLAS PERFECT VISION GMBH; VALEANT CANADA LP; VALEANT PHARMACEUTICALS INTERNATIONAL; VALEANT PHARMACEUTICALS INTERNATIONAL, INC.; VALEANT PHARMACEUTICALS NORTH AMERICA LLC; WIRRA IP PTY LIMITED; VALEANT PHARMA POLAND SP. Z O.O.; VALEANT PHARMACEUTICALS LUXEMBOURG S.A R.L.; VALEANT PHARMACEUTICALS IRELAND LIMITED
Reel/Frame 073637/0001 →
RELEASE OF SECURITY INTEREST Recorded Nov 20, 2025
From: THE BANK OF NEW YORK MELLON, AS NOTES COLLATERAL AGENT
To: BAUSCH HEALTH AMERICAS, INC.; BAUSCH & LOMB INCORPORATED; BAUSCH HEALTH US, LLC; SOLTA MEDICAL, INC.; MEDICIS PHARMACEUTICAL CORPORATION; SALIX PHARMACEUTICALS, INC.; SALIX PHARMACEUTICALS, LTD.; SANTARUS, INC.; ORAPHARMA, INC.; PRECISION DERMATOLOGY, INC.
Reel/Frame 073637/0126 →
RELEASE OF SECURITY INTEREST Recorded Nov 20, 2025
From: THE BANK OF NEW YORK MELLON, AS NOTES COLLATERAL AGENT
To: BAUSCH HEALTH IRELAND LIMITED; BAUSCH HEALTH COMPANIES INC.; BAUSCH HEALTH, CANADA INC.; TECHNOLAS PERFECT VISION GMBH; VALEANT PHARMACEUTICALS LUXEMBOURG S.A R.L.; VALEANT PHARMA POLAND SPOLKA Z ORGANICZONA ODPOWIEDZIALNOSCIA; VALEANT SP. Z.O.O.
Reel/Frame 073637/0222 →
RELEASE OF SECURITY INTEREST Recorded Nov 20, 2025
From: THE BANK OF NEW YORK MELLON, AS NOTES COLLATERAL AGENT
To: BAUSCH & LOMB INCORPORATED; BAUSCH HEALTH US, LLC; SOLTA MEDICAL, INC.; MEDICIS PHARMACEUTICAL CORPORATION; SALIX PHARMACEUTICALS, INC.; SALIX PHARMACEUTICALS, LTD.; SANTARUS, INC.; ORAPHARMA, INC.; PRECISION DERMATOLOGY, INC.; BAUSCH HEALTH AMERICAS, INC.
Reel/Frame 073654/0242 →
U.S. PATENT SECURITY AGREEMENT Recorded Jun 13, 2025
From: MEDICIS PHARMACEUTICAL CORPORATION; ORAPHARMA, INC.; BAUSCH HEALTH US, LLC (F/K/A VALEANT PHARMACEUTICALS NORTH AMERICA LLC); PRECISION DERMATOLOGY, INC.; SALIX PHARMACEUTICALS, INC.; SANTARUS, INC.; BAUSCH HEALTH AMERICAS, INC.; SOLTA MEDICAL, INC.
To: THE BANK OF NEW YORK MELLON
Reel/Frame 071564/0463 →
U.S. PATENT SECURITY AGREEMENT Recorded Jun 13, 2025
From: MEDICIS PHARMACEUTICAL CORPORATION; ORAPHARMA, INC.; BAUSCH HEALTH US, LLC (F/K/A VALEANT PHARMACEUTICALS NORTH AMERICA LLC); PRECISION DERMATOLOGY, INC.; SALIX PHARMACEUTICALS, INC.; SANTARUS, INC.; BAUSCH HEALTH AMERICAS, INC.; SOLTA MEDICAL, INC.
To: JPMORGAN CHASE BANK, N.A.
Reel/Frame 071566/0200 →
RELEASE OF SECURITY INTEREST Recorded Apr 8, 2025
From: BARCLAYS BANK PLC, AS COLLATERAL AGENT
To: SOLTA MEDICAL, INC.; PRECISION DERMATOLOGY, INC.; BAUSCH HEALTH IRELAND LIMITED (F/K/A/ VALEANT PHARMACEUTICALS IRELAND LIMITED); SALIX PHARMACEUTICALS, INC.; SALIX PHARMACEUTICALS, LTD; SANTARUS, INC.; MEDICIS PHARMACEUTICAL CORPORATION; HUMAX PHARMACEUTICAL S.A.; SOLTA MEDICAL IRELAND LIMITED; BAUSCH & LOMB MEXICO, S.A. DE C.V.; BAUSCH+LOMB OPS B.V.; BAUSCH HEALTH AMERICAS, INC.; BAUSCH HEALTH COMPANIES INC.; BAUSCH HEALTH HOLDCO LIMITED; BAUSCH HEALTH MAGYARORSZAG KFT (A/K/A BAUSCH HEALTH HUNGARY LLC); BAUSCH HEALTH POLAND SPOLKA Z OGRANICZONA ODPOWIEDZIALNOSCIA (F/K/A VALEANT PHARMA POLAND SPOLKA Z OGRANICZONA ODPOWIEDZIALNOSCIA); BAUSCH HEALTH US, LLC; BAUSCH HEALTH, CANADA INC. / SANTE BAUSCH, CANADA INC.; ICN POLFA RZESZOW SPOLKA AKCYJNA (A/K/A ICN POLFA RZESZOW S.A.); ORAPHARMA, INC.; PRZEDSIEBIORSTWO FARMACEUTYCZNE JELFA SPOLKA AKCYJNA (A/K/A PRZEDSIEBIORSTWO FARMACEUTYCZNE JELFA S.A.); SOLTA MEDICAL DUTCH HOLDINGS B.V.; V-BAC HOLDING CORP.; VRX HOLDCO LLC; 1261229 B.C. LTD.; 1530065 B.C. LTD.
Reel/Frame 070778/0199 →
SECURITY AGREEMENT (SECOND LIEN) Recorded Oct 5, 2022
From: BAUSCH HEALTH US, LLC; BAUSCH HEALTH AMERICAS, INC.; MEDICIS PHARMACEUTICAL CORPORATION; ORAPHARMA, INC.; PRECISION DERMATOLOGY, INC.; SALIX PHARMACEUTICALS, INC.; SALIX PHARMACEUTICALS, LTD.; SANTARUS, INC.; SOLTA MEDICAL, INC.
To: THE BANK OF NEW YORK MELLON, AS NOTES COLLATERAL AGENT
Reel/Frame 061606/0468 →
SECURITY AGREEMENT (FIRST LIEN) Recorded Oct 4, 2022
From: BAUSCH HEALTH US, LLC; BAUSCH HEALTH AMERICAS, INC.; MEDICIS PHARMACEUTICAL CORPORATION; ORAPHARMA, INC.; PRECISION DERMATOLOGY, INC.; SALIX PHARMACEUTICALS, INC.; SALIX PHARMACEUTICALS, LTD.; SANTARUS, INC.; SOLTA MEDICAL, INC.
To: THE BANK OF NEW YORK MELLON, AS NOTES COLLATERAL AGENT
Reel/Frame 061595/0066 →
SECURITY AGREEMENT Recorded Feb 10, 2022
From: BAUSCH & LOMB INCORPORATED; BAUSCH HEALTH US, LLC; SOLTA MEDICAL, INC.; MEDICIS PHARMACEUTICAL CORPORATION; SALIX PHARMACEUTICALS, INC.; SALIX PHARMACEUTICALS, LTD.; SANTARUS, INC.; ORAPHARMA, INC.; PRECISION DERMATOLOGY, INC.; BAUSCH HEALTH AMERICAS, INC.
To: THE BANK OF NEW YORK MELLON
Reel/Frame 059121/0001 →
SECURITY INTEREST Recorded Jun 8, 2021
From: BAUSCH & LOMB INCORPORATED; BAUSCH HEALTH US, LLC; SOLTA MEDICAL, INC.; MEDICIS PHARMACEUTICAL CORPORATION; SALIX PHARMACEUTICALS, INC.; SALIX PHARMACEUTICALS, LTD.; SANTARUS, INC.; ORAPHARMA, INC.; PRECISION DERMATOLOGY, INC.; BAUSCH HEALTH AMERICAS, INC.
To: THE BANK OF NEW YORK MELLON, AS NOTES COLLATERAL AGENT
Reel/Frame 056811/0814 →
INTELLECTUAL PROPERTY SECURITY AGREEMENT Recorded Jul 3, 2019
From: BAUSCH HEALTH IRELAND LIMITED; BAUSCH HEALTH COMPANIES INC.; BAUSCH HEALTH, CANADA INC.; TECHNOLAS PERFECT VISION GMBH; VALEANT PHARMACEUTICALS LUXEMBOURG S.À R.L.; VALEANT PHARMA POLAND SPOLKA Z OGRANICZONA ODPOWIEDZIALNOSCIA; VALEANT SP. Z O. O.
To: THE BANK OF NEW YORK MELLON, AS COLLATERAL AGENT
Reel/Frame 049672/0652 →
SECURITY INTEREST Recorded Mar 11, 2019
From: BAUSCH HEALTH AMERICAS, INC.; BAUSCH & LOMB INCORPORATED; BAUSCH HEALTH US, LLC; SOLTA MEDICAL, INC.; MEDICIS PHARMACEUTICAL CORPORATION; SALIX PHARMACEUTICALS, INC.; SALIX PHARMACEUTICALS, LTD.; SANTARUS, INC.; ORAPHARMA, INC.; PRECISION DERMATOLOGY, INC.
To: THE BANK OF NEW YORK MELLON, AS NOTES COLLATERAL AGENT
Reel/Frame 048556/0758 →
SECURITY INTEREST Recorded Feb 26, 2018
From: ATON PHARMA, INC.; BAUSCH & LOMB INCORPORATED; BAUSCH & LOMB PHARMA HOLDINGS CORP.; COMMONWEALTH LABORATORIES, LLC; DOW PHARMACEUTICAL SCIENCES, INC.; ECR PHARMACEUTICALS CO., INC.; LABORATOIRE CHAUVIN S.A.S.; MEDICIS PHARMACEUTICAL CORPORATION; ONPHARMA INC.; ORAPHARMA, INC.; PRECISION DERMATOLOGY, INC.; SALIX PHARMACEUTICALS, LTD.; SALIX PHARMACEUTICALS, INC.; SANTARUS, INC.; SOLTA MEDICAL, INC.; SYNERGETICS USA, INC.; TECHNOLAS PERFECT VISION GMBH; VALEANT CANADA LP; VALEANT PHARMACEUTICALS INTERNATIONAL; VALEANT PHARMACEUTICALS INTERNATIONAL, INC.; VALEANT PHARMACEUTICALS NORTH AMERICA LLC; WIRRA IP PTY LIMITED; VALEANT PHARMA POLAND SP. Z O.O.; VALEANT PHARMACEUTICALS LUXEMBOURG S.A R.L.; VALEANT PHARMACEUTICALS IRELAND LIMITED
To: THE BANK OF NEW YORK MELLON, AS COLLATERAL AGENT
Reel/Frame 045444/0634 →
SECURITY INTEREST Recorded Feb 26, 2018
From: ATON PHARMA, INC.; BAUSCH & LOMB INCORPORATED; BAUSCH & LOMB PHARMA HOLDINGS CORP.; COMMONWEALTH LABORATORIES, LLC; DOW PHARMACEUTICAL SCIENCES, INC.; ECR PHARMACEUTICALS CO., INC.; LABORATOIRE CHAUVIN S.A.S.; MEDICIS PHARMACEUTICAL CORPORATION; ONPHARMA INC.; ORAPHARMA, INC.; PRECISION DERMATOLOGY, INC.; SALIX PHARMACEUTICALS, LTD.; SALIX PHARMACEUTICALS, INC.; SANTARUS, INC.; SOLTA MEDICAL, INC.; SYNERGETICS USA, INC.; TECHNOLAS PERFECT VISION GMBH; VALEANT CANADA LP; VALEANT PHARMACEUTICALS INTERNATIONAL; VALEANT PHARMACEUTICALS INTERNATIONAL, INC.; VALEANT PHARMACEUTICALS NORTH AMERICA LLC; WIRRA IP PTY LIMITED; VALEANT PHARMA POLAND SP. Z O.O.; VALEANT PHARMACEUTICALS LUXEMBOURG S.A R.L.; VALEANT PHARMACEUTICALS IRELAND LIMITED
To: BARCLAYS BANK PLC, AS COLLATERAL AGENT
Reel/Frame 045444/0299 →
SECURITY INTEREST Recorded Jul 19, 2017
From: PRECISION DERMATOLOGY, INC.
To: THE BANK OF NEW YORK MELLON
Reel/Frame 043041/0864 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Apr 20, 2016
From: GURGE, RONALD M.; TRUMBORE, MARK W.; CHIN, LISA; HIRANI, POONAM SHAMBHU
To: PRECISION DERMATOLOGY, INC.
Reel/Frame 038333/0122 →
SECURITY AGREEMENT Recorded Jul 6, 2015
From: VALEANT PHARMACEUTICALS INTERNATIONAL, INC.
To: BARCLAYS BANK PLC, AS COLLATERAL AGENT
Reel/Frame 036064/0372 →