Oligomer-protein tyrosine kinase inhibitor conjugates
View Patent ↗The invention relates to (among other things) oligomer-PTK inhibitor conjugates and related compounds. A compound of the invention, when administered by any of a number of administration routes, exhibits advantages over PTK inhibitor compounds lacking a water-soluble, non-peptidic oligomer.
1. A method for inhibiting a protein tyrosine kinase, the method comprising administering to a mammal a protein tyrosine kinase-inhibiting amount of a compound having the following structure
or a pharmaceutically acceptable salt thereof, wherein X is a spacer moiety and POLY is a water-soluble, non-peptidic oligomer having from about 1 to about 30 monomers.
2. The method of claim 1 , wherein X is a spacer moiety that includes a bivalent peptidic moiety of an amino acid.
3. The method of claim 1 , wherein the water-soluble, non-peptidic oligomer is a poly(alkylene oxide).
4. The method of claim 3 , wherein the poly(alkylene oxide) is a poly(ethylene oxide).
5. The method of claim 1 , wherein the water-soluble, non-peptidic oligomer has from about 1 to about 10 monomers.
6. The method of claim 1 , wherein the poly(alkylene oxide) includes an alkoxy or hydroxy end-capping moiety.
7. The method of claim 1 , wherein the compound has the following structure
wherein n is 1 to 30; and X is a peptidic moiety of a bivalent amino acid.
8. The method of claim 1 , wherein the compound has a structure selected from the group consisting of:
wherein n is 1 to 30.