Vascular closure device

1. A vascular closure device comprising:

a preshaped, cylindrical fibrous plug formed prior to delivery from a nonwoven fabric of at least one randomly oriented and entangled fiber, the thickness of the nonwoven fabric ranging from about 0.25 to 2 mm, the basis weight of the nonwoven fabric ranging from about 0.01 to 0.2 g/in 2 , the at least one randomly oriented fiber having a density from about 120 to about 150 denier and a tenacity from about 3 to about 7 g/denier, the cylindrical fibrous plug being configured for occluding blood flow from a puncture and sealing a wound in a tract of a puncture wound, the fibrous plug having a definite cylindrical shape and volume ex vivo, the randomly oriented fiber comprising at least one polymer; and

at least one agent, in therapeutic dosage, dispersed in the fiber matrix of the at least one randomly oriented fiber, and configured for controlled elution therefrom, the at least one agent comprises an agent selected from a group consisting of anti-proliferative agents, anti-thrombogenic agents, anti-restenotic agents, anti-viral agents, anti-inflammatory agents, cytostatic agents, immunosuppressive agents, anti-calcification agents, anti-encrustation agents, statins, hormones, anti-cancer agents, anti-coagulants, anti-migratory agents, tissue growth promoting agents, heparin, and combinations thereof.

2. The vascular closure device according to claim 1 , wherein the at least one polymer comprises a blend of one or more polymers.

3. The vascular closure device according to claim 1 , wherein the at least one polymer comprises a blend of at least one polymer and at least one plasticizer.

4. The vascular closure device according to claim 1 , wherein the at least one polymer comprises a bioabsorbable polymer.