Oligomer-cannabinoid conjugates
View Patent ↗The invention relates to (among other things) oligomer-cannabinoid conjugates and related compounds. A conjugate of the invention, when administered by any of a number of administration routes, exhibits advantages over previously administered un-conjugated cannabinoid compounds.
1. A compound having the following structure:
wherein X is a spacer moiety and POLY is a poly(ethylene oxide).
2. The compound of claim 1 , wherein the poly(ethylene oxide) is made of between 1 and 30 monomers.
3. The compound of claim 2 , wherein the poly(ethylene oxide) is made of between 1 and 10 monomers.
4. The compound of claim 1 , wherein the poly(ethylene oxide) includes an alkoxy or hydroxy end-capping moiety.
5. The compound of claim 1 , wherein X is —O—, —S—, —NH—, —C(O)—NH—, —NH—C(O)—, —NH—C(O)—O—, —NH—C(O)—NH—, or a covalent bond.
6. The compound of claim 1 , wherein X is —O—.
7. A composition comprising a compound of claim 1 , and optionally, a pharmaceutically acceptable excipient.
8. A composition of matter comprising a compound of claim 1 , wherein the compound is present in a dosage form.
9. A compound having the structure:
wherein n is an integer having a value of from 1 to 9.
10. A composition comprising a compound of claim 9 , and optionally, a pharmaceutically acceptable excipient.
11. A composition of matter comprising a compound of claim 9 , wherein the compound is present in a dosage form.