IP Library Granted Patent US 8,962,635
Granted Patent B2
US 8,962,635 · App. 14/341,421 · Granted Feb 24, 2015

Tyrosine kinase inhibitors

Inventor: David Michael Goldstein (Redwood City, CA)
Assignee: Principia Biopharma Inc.
C07D487/10
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Quick Facts
Patent No.
US 8,962,635
App. No.
14/341,421
Granted
Feb 24, 2015
Kind
B2
Abstract

The present disclosure provides compounds and pharmaceutically acceptable salts thereof that are tyrosine kinase inhibitors, in particular BLK, BMX, EGFR, HER2, HER4, ITK, TEC, BTK, and TXK and are therefore useful for the treatment of diseases treatable by inhibition of tyrosine kinases such as cancer and inflammatory diseases such as arthritis, and the like. Also provided are pharmaceutical compositions containing such compounds and pharmaceutically acceptable salts thereof and processes for preparing such compounds and pharmaceutically acceptable salts thereof.

Claims (1)

1. 3-[(3R)-3-[4-amino-3-(2-fluoro-4-phenoxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl]piperidin-1-yl]-3-oxopropanenitrile having the structure

Assignments (3)
ASSIGNEE CHANGE OF ADDRESS Recorded Sep 16, 2025
From: PRINCIPIA BIOPHARMA INC.
To: PRINCIPIA BIOPHARMA INC.
Reel/Frame 072881/0270 →
ASSIGNEE CHANGE OF ADDRESS Recorded Mar 22, 2019
From: PRINCIPIA BIOPHARMA INC.
To: PRINCIPIA BIOPHARMA INC.
Reel/Frame 048675/0297 →
ASSIGNMENT OF ASSIGNOR'S INTEREST Recorded Mar 15, 2019
From: GOLDSTEIN, DAVID MICHAEL; BRAMELD, KENNETH ALBERT
To: PRINCIPIA BIOPHARMA INC.
Reel/Frame 048616/0498 →
Continuity (2)
Continuation 13859569 · Apr 9, 2013
Related Publication 20140336382A1 · Nov 13, 2014