Methods and composition for inducing satiety
A flowable or spoonable medicament, food, food ingredient or food supplement is useful for inducing satiety. It comprises (a) one or more mono-, di- and/or oligosaccharides and (b) a methylcellulose, wherein the methylcellulose has anhydroglucose units joined by 1-4 linkages wherein hydroxy groups of anhydroglucose units are substituted with methyl groups such that s23/s26 is from 0.17 to 0.36, wherein s23 is the molar fraction of anhydroglucose units wherein only the two hydroxy groups in the 2- and 3-positions of the anhydroglucose unit are substituted with methyl groups and wherein s26 is the molar fraction of anhydroglucose units wherein only the two hydroxy groups in the 2- and 6-positions of the anhydroglucose unit are substituted with methyl groups.
1. A flowable or spoonable medicament, food, food ingredient or food supplement comprising (a) one or more mono-, di- and/or oligosaccharides and (b) a methylcellulose, wherein the methylcellulose has anhydroglucose units joined by 1-4 linkages wherein hydroxy groups of anhydroglucose units are substituted with methyl groups such that s23/s26 is from 0.17 to 0.36,
wherein s23 is the molar fraction of anhydroglucose units wherein only the two hydroxy groups in the 2- and 3-positions of the anhydroglucose unit are substituted with methyl groups and
wherein s26 is the molar fraction of anhydroglucose units wherein only the two hydroxy groups in the 2- and 6-positions of the anhydroglucose unit are substituted with methyl groups
wherein the methylcellulose has a viscosity of from 200 to 10,000 mPa·s, measured as 2 wt. % aqueous solution at 5° C. at a shear rate of 10 s −1 , and
wherein the weight ratio of (a) the total of one or more mono-, di- and/or oligosaccharides and (b) the methylcellulose is from 2.0:1.0 to 20:1.0.
2. The medicament, food, food ingredient or food supplement of claim 1 , wherein the methylcellulose has a DS(methyl) of from 1.55 to 2.25.
3. The medicament, food, food ingredient or food supplement of claim 1 , wherein the methylcellulose has a viscosity of from 400 to 7000 mPa·s, measured as 2 wt. % aqueous solution at 5° C. at a shear rate of 10 s −1 .
4. The medicament, food, food ingredient or food supplement of claim 1 , wherein the weight ratio of (a) the total of one or more mono-, di- and/or oligosaccharides and (b) the methylcellulose is from 5.0:1.0 to 15:1.0.
5. The medicament, food, food ingredient or food supplement of claim 1 , wherein the medicament, food, food ingredient or food supplement is useful for indications that require gastric volume to be occupied for at least 60 minutes.
6. The medicament, food, food ingredient or food supplement of claim 1 , that when ingested by an individual, forms a gel mass in the individual's stomach.
7. The medicament, food, food ingredient or food supplement of claim 1 , wherein the medicament, food, food ingredient or food supplement additionally comprises an aqueous liquid and the amount of the methylcellulose is from 0.5 to 2.5 weight percent, based on the total weight of the liquid composition.
8. The medicament, food, food ingredient or food supplement of claim 1 being in powder or granular form designed to be mixed with an aqueous liquid before consumption.
9. The food, food ingredient or food supplement of claim 1 , wherein the food, food ingredient or food supplement is useful as a slimming aid, weight loss aid, or weight control aid in a non-obese individual.
10. The medicament of claim 1 , wherein the medicament is useful for treating gastric ulcers, gastro-esophageal reflux disease, or obesity.
11. A method for inducing satiety or for reversibly reducing stomach void volume in an individual, comprising administering to said individual the medicament, food, food ingredient or food supplement of claim 1 .
12. A method of reducing caloric intake in an individual, comprising administering to said individual the medicament, food, food ingredient or food supplement of claim 1 .
13. The method of claim 11 , wherein the medicament, food, food ingredient or food supplement is administered at least 45 minutes before the individual eats.
14. The method of claim 11 , wherein the individual is obese.
15. The method of claim 11 , wherein the individual is not obese.
16. The method of claim 12 , wherein the medicament, food, food ingredient or food supplement is administered at least 45 minutes before the individual eats.
17. The method of claim 12 , wherein the individual is obese.
18. The method of claim 12 , wherein the individual is not obese.
19. The medicament, food, food ingredient or food supplement of claim 1 , wherein said one or more mono-, di- and/or oligosaccharides are selected from the group consisting of mono- and disaccharides.