Methods and composition for inducing satiety
A flowable or spoonable medicament, food, food ingredient or food supplement is useful for inducing satiety. It comprises a protein and a methylcellulose (MC), wherein the weight ratio w(protein)/w(MC) is at least 0.7/1.0 and the methylcellulose has anhydroglucose units joined by 1-4 linkages wherein hydroxy groups of anhydroglucose units are substituted with methyl groups such that s23/s26 is 0.36 or less, wherein s23 is the molar fraction of anhydroglucose units wherein only the two hydroxy groups in the 2- and 3-positions of the anhydroglucose unit are substituted with methyl groups and wherein s26 is the molar fraction of anhydroglucose units wherein only the two hydroxy groups in the 2- and 6-positions of the anhydroglucose unit are substituted with methyl groups.
1. A flowable or spoonable medicament, food, food ingredient or food supplement comprising a protein and a methylcellulose, wherein
the weight ratio w(protein)/w(methylcellulose) is at least 0.7/1.0 and
the methylcellulose has anhydroglucose units joined by 1-4 linkages wherein hydroxy groups of anhydroglucose units are substituted with methyl groups such that s23/s26 is 0.36 or less,
wherein s23 is the molar fraction of anhydroglucose units wherein only the two hydroxy groups in the 2- and 3-positions of the anhydroglucose unit are substituted with methyl groups and
wherein s26 is the molar fraction of anhydroglucose units wherein only the two hydroxy groups in the 2- and 6-positions of the anhydroglucose unit are substituted with methyl groups.
2. The medicament, food, food ingredient or food supplement of claim 1 , wherein the methylcellulose has a DS(methyl) of from 1.55 to 2.25.
3. The medicament, food, food ingredient or food supplement of claim 1 , wherein the weight ratio w(protein)/w(methylcellulose) is from 2.0/1.0 to 40/1.0.
4. The medicament, food, food ingredient or food supplement of claim 1 , wherein the medicament, food, food ingredient or food supplement is useful for indications that require gastric volume to be occupied for at least 60 minutes.
5. The medicament, food, food ingredient or food supplement of claim 1 , that when ingested by an individual, forms a gel mass in the individual's stomach.
6. The medicament, food, food ingredient or food supplement of claim 1 , wherein the medicament, food, food ingredient or food supplement additionally comprises an aqueous liquid and the amount of the methylcellulose is 1.0 to 2.5 weight percent, based on the total weight of the liquid composition.
7. The medicament, food, food ingredient or food supplement of claim 1 being in powder or granular form designed to be mixed with an aqueous liquid before consumption.
8. The food, food ingredient or food supplement of claim 1 , wherein the food, food ingredient or food supplement is useful as a slimming aid, weight loss aid, or weight control aid in a non-obese individual.
9. The medicament of claim 1 , wherein the medicament is useful for treating gastric ulcers, gastro-esophageal reflux disease, or obesity.
10. A method for inducing satiety or for reversibly reducing stomach void volume in an individual, comprising administering to said individual the medicament, food, food ingredient or food supplement of claim 1 .
11. A method of reducing caloric intake in an individual, comprising administering to said individual the medicament, food, food ingredient or food supplement of claim 1 .
12. The method of claim 10 , wherein the medicament, food, food ingredient or food supplement is administered at least 45 minutes before the individual eats.
13. The method of claim 10 , wherein the individual is obese.
14. The method of claim 10 , wherein the individual is not obese.
15. The medicament, food, food ingredient or food supplement of claim 1 , wherein the methylcellulose has anhydroglucose units joined by 1-4 linkages wherein hydroxy groups of anhydroglucose units are substituted with methyl groups such that s23/s26 is 0.24 or less.
16. The method of claim 11 , wherein the medicament, food, food ingredient or food supplement is administered at least 45 minutes before the individual eats.
17. The method of claim 11 , wherein the individual is obese.
18. The method of claim 11 , wherein the individual is not obese.
19. The medicament, food, food ingredient or food supplement of claim 1 wherein the protein is a soy protein in the form of an isolated protein, a protein concentrate or a protein hydrolysate and the weight ratio w(protein)/w(methylcellulose) is from 0.7/1.0 to 20/1.0.
20. The medicament, food, food ingredient or food supplement of claim 1 wherein the protein is a dairy protein in the form of an isolated protein, a protein concentrate or a protein hydrolysate and the weight ratio w(protein)/w(methylcellulose) is from 2.25/1.0 to 40/1.0.