ADJUVANTED INFLUENZA B VIRUS VACCINES FOR PEDIATRIC PRIMING
The influenza B strain is epidemiologically relevant in the pediatric population. Immunogenic priming of children with influenza B vaccine adjuvanted with an oil-in-water emulsion primes an immune response to a booster vaccine comprising influenza B virus antigen from a different strain or lineage, irrespective of whether the booster comprises an adjuvant.
1 - 16 . (canceled)
17 . A method for immunizing a subject, the method comprising a step of:
administering to a subject a single booster dose of an immunogenic composition comprising an antigen from a second B strain,
wherein the subject is up to 8 years of age and has received at least one priming dose of an immunogenic composition comprising an antigen from a first B strain and an adjuvant comprising an oil-in-water emulsion.
18 . The method of claim 17 , wherein the single booster dose is administered about two years after the priming dose.
19 . The method of claim 17 , wherein the subject has received two priming doses of the immunogenic composition.
20 . The method of claim 17 , wherein the single booster dose does not comprise an adjuvant.
21 . The method claim 17 , wherein the majority of oil droplets in the oil-in-water emulsion have a diameter of less than 1 μm.
22 . The method claim 17 , wherein the oil-in-water emulsion comprises squalene.
23 . The method of claim 17 , wherein the first B strain and the second B strain are in different lineages.
24 . The method of claim 17 , wherein the subject is between 6 and 72 months old.
25 . The method of claim 17 , wherein the priming dose and/or the single booster dose includes antigen from a H1N1 influenza A virus and antigen from a H3N2-type influenza A virus.
26 . The method of claim 17 , wherein the immunogenic composition of the single booster dose is a whole virus vaccine, a split virus vaccine, or a subunit vaccine.
27 . The method of claim 17 , further comprising a step of:
administering to the subject, prior to the administration of the single booster dose, at least one priming dose of an immunogenic composition comprising an antigen from a first B strain and an adjuvant comprising an oil-in-water emulsion.
28 . The method of claim 27 , wherein the priming dose and/or the single booster dose includes antigen from a H1N1 influenza A virus and antigen from a H3N2-type influenza A virus.
29 . The method of claim 27 , wherein the majority of oil droplets in the oil-in-water emulsion have a diameter of less than 1 μm.
30 . The method of claim 27 , wherein oil-in-water emulsion comprises squalene.
31 . The method of claim 27 , wherein the immunogenic composition of the single booster dose is a whole virus vaccine, a split virus vaccine, or a subunit vaccine.