Compounds that modulate intracellular calcium
View Patent ↗Described herein are compounds and pharmaceutical compositions containing such compounds, which modulate the activity of store-operated calcium (SOC) channels. Also described herein are methods of using such SOC channel modulators, alone and in combination with other compounds, for treating diseases or conditions that would benefit from inhibition of SOC channel activity.
1. A compound having the structure of Formula (I):
wherein:
X is CH or N;
R 1 is Cl or CH 3 ;
each R 2 is independently selected from halogen, C 1 -C 6 alkyl, and C 1 -C 6 haloalkyl;
R 3 is C 1 -C 6 alkyl, C 1 -C 6 haloalkyl, or C 3 -C 8 cycloalkyl;
m is an integer selected from 0-3;
n is an integer selected from 0-2;
p is an integer selected from 1-2;
or a pharmaceutically acceptable salt, or pharmaceutically acceptable solvate thereof.
2. The compound of claim 1 wherein X is CH.
3. The compound of claim 2 wherein A is
4. The compound of claim 3 wherein n is 1.
5. The compound of claim 4 wherein R 2 is C 1 -C 6 alkyl.
6. The compound of claim 4 wherein R 2 is halogen.
7. The compound of claim 3 wherein n is 2.
8. The compound of claim 7 wherein each R 2 is independently selected from halogen, C 1 -C 6 alkyl, and C 1 -C 6 haloalkyl.
9. The compound of claim 8 wherein each R 2 is independently selected from Cl, CH 3 , and CF 3 .
10. The compound of claim 3 wherein R 3 is C 1 -C 6 alkyl.
11. The compound of claim 1 wherein X is N.
12. The compound of claim 11 wherein A is
13. The compound of claim 12 wherein n is 1.
14. The compound of claim 13 wherein R 2 is C 1 -C 6 alkyl.
15. The compound of claim 13 wherein R 2 is halogen.
16. The compound of claim 12 wherein n is 2.
17. The compound of claim 16 wherein each R 2 is independently selected from halogen, C 1 -C 6 alkyl, and C 1 -C 6 haloalkyl.
18. The compound of claim 17 wherein each R 2 is independently selected from Cl, CH 3 , and CF 3 .
19. The compound of claim 12 wherein R 3 is C 1 -C 6 alkyl.
20. A pharmaceutical composition comprising a pharmaceutically acceptable diluent, excipient or binder, and a compound of claim 1 or a pharmaceutically acceptable salt, or pharmaceutically acceptable solvate thereof.