Nitric oxide releasing bath compositions and methods of using the same
The present invention relates to bath compositions that may release nitric oxide when combined with an aqueous solution, thereby producing a nitric oxide releasing soak and/or bath. The present invention also relates to methods of using nitric oxide releasing bath compositions.
1. A bath composition comprising:
sodium bicarbonate at a concentration in a range from about 30% to about 60% by weight of the bath composition;
citric acid and/or tartaric acid at a concentration in a range from about 0.1% to about 5% by weight of the bath composition; and
at least one nitric oxide (NO)-releasing compound, wherein the at least one NO-releasing compound comprises a NO-releasing macromolecule comprising diazeniumdiolate-functionalized co-condensed silica at a concentration in a range from about 35% to about 65% by weight of the bath composition, wherein the diazeniumdiolate-functionalized cocondensed silica has a half-life of greater than about 60 minutes at 37° C. and pH 7.4, and wherein the bath composition provides a total NO release of about 1 mmol NO/L to about 100 mmol NO/L.
2. The bath composition of claim 1 , wherein the at least one NO-releasing compound releases NO upon reaction with water.
3. The bath composition of claim 1 , wherein the concentration of the diazeniumdiolate-functionalized co-condensed silica is in a range from about 35% to about 55% by weight of the bath composition.
4. The bath composition of claim 1 , wherein the sodium bicarbonate is present at a concentration in a range from about 35% to about 50% by weight of the bath composition.
5. The bath composition of claim 1 , wherein the citric acid and/or tartaric acid is present at a concentration in a range from about 0.2% to about 2% by weight of the bath composition.
6. The bath composition of claim 1 , further comprising an aromatherapy agent, wherein the concentration of the aromatherapy agent is in a range from about 0.1% to about 10% by weight of the bath composition.
7. The bath composition of claim 1 , further comprising a glidant, wherein the concentration of the glidant is in a range from about 0.1% to about 10% by weight of the bath composition.
8. The bath composition of claim 1 , further comprising an inert filler, wherein the concentration of the inert filler is in a range from about 0.1% to about 60% by weight of the bath composition.
9. The bath composition of claim 1 , wherein the diazeniumdiolate-functionalized co-condensed silica has an octanol/water partition coefficient in a range from 0.1 to 7.
10. The bath composition of claim 1 , wherein the diazeniumdiolate-functionalized co-condensed silica is present as particles and the particles have a hydrodynamic radius in a range from about 1 nm to about 10 microns.
11. The bath composition of claim 1 , wherein the diazeniumdiolate-functionalized co-condensed silica is present as particles and the nitric oxide storage of the diazeniumdiolate-functionalized co-condensed silica particles is in a range from about 0.1 pmol NO/g to about 1 mmol NO/g of the bath composition.
12. The bath composition of claim 1 , wherein the bath composition is in the form of a powder, a bead, a granule, a tablet, a film, a coating, a film-coated tablet, a polymer sheet, and any combination thereof.
13. The bath composition of claim 1 , wherein the composition further comprises at least one compound that provides a visual indicator of when NO, nitrous acid and/or salts thereof are present.
14. A method of treating a subject comprising: contacting the bath composition of claim 1 with an aqueous solution to form NO, thereby producing a nitric oxide releasing bath, and exposing at least a portion of the subject to the bath.
15. The method of claim 14 , further comprising adjusting the release rate of the NO by changing the temperature of the bath and/or modifying the pH of the bath.
16. The bath composition of claim 6 , wherein the aromatherapy agent is selected from menthol and/or camphor.
17. The bath composition of claim 7 , wherein the glidant is selected from colloidal silicon dioxide and/or talc.
18. The bath composition of claim 8 , wherein the inert filler is selected from microcrystalline cellulose and/or lactose.
19. The bath composition of claim 1 , wherein the bath composition is present as a coating on a surface of a container.